Stenbeck G, Schreiner R, Herrmann D, Auerbach S, Lottspeich F, Rothman J E, Wieland F T
Institut für Biochemie I, Universität Heidelberg, Germany.
FEBS Lett. 1992 Dec 14;314(2):195-8. doi: 10.1016/0014-5793(92)80973-k.
Constitutive secretory transport in eukaryotes is likely to be mediated by non-clathrin-coated vesicles, which have been isolated and characterized [(1989) Cell 58, 329-336; (1991) Nature 349, 215-220]. They contain a set of coat proteins (COPs) which are also likely to exist in a preformed cytosolic complex named coatomer [(1991) Nature 349, 248-250]. From peptide sequence and cDNA structure comparisons evidence is presented that one of the subunits of coatomer, gamma-COP, is a true constituent of non-clathrin-coated vesicles, and that gamma-COP is related to sec 21, a secretory mutant of the yeast Saccharomyces cervisiae.
