Int J Gynaecol Obstet. 1992 Nov;39(3):185-96.
To assess the current situation in pregnancy drug prescription across various cultural and health care settings.
An international study was set up to collect by questionnaire survey comparable data. A total of 14,778 women giving birth in 148 hospitals from 22 countries were enrolled.
Antenatally, 14% of women received no drugs, while drug takers received an average of 2.9 prescriptions. There were marked intercountry variations in prescribing habits. The majority of prescriptions referred to iron and vitamins. Anti-infectives were the second most widely taken drugs. Anti-inflammatory drugs were taken by 17% of women, these in 42% of cases being self-administered. During the intrapartum period 79% of the women received an average of 3.3 drugs. Besides analgesics/anesthetics (31.8%), the most commonly prescribed drugs were oxytocin (17.5%), ergot derivatives (8.4%) and anti-infectives (5.3%). At the time of interview 91% of women were planning to breastfeed. Methylergometrin led the list of most frequently used drugs (36%) given to breastfeeding women, although the use of ergot derivatives in the puerperium showed wide intercountry variations.
The survey has confirmed that at present, some drugs are often more widely used in pregnancy than is justified by the knowledge available.
评估不同文化和医疗环境下孕期用药的现状。
开展一项国际研究，通过问卷调查收集可比数据。来自22个国家的148家医院的14778名分娩妇女参与了研究。
产前，14%的妇女未用药，而用药者平均接受2.9种处方。各国的用药习惯存在显著差异。大多数处方涉及铁剂和维生素。抗感染药物是第二大最常用药物。17%的妇女使用抗炎药物，其中42%的情况是自行用药。在分娩期，79%的妇女平均接受3.3种药物。除了镇痛药/麻醉药（31.8%）外，最常用的药物是缩宫素（17.5%）、麦角衍生物（8.4%）和抗感染药物（5.3%）。在访谈时，91%的妇女计划进行母乳喂养。甲基麦角新碱是给哺乳期妇女使用的最常用药物之首（36%），尽管产后麦角衍生物的使用在各国存在很大差异。
该调查证实，目前一些药物在孕期的使用往往比现有知识所证明的更为广泛。
