Park M H, Park Y B
Department of Clinical Pathology, Seoul National University College of Medicine, Korea.
Heart Vessels Suppl. 1992;7:81-4. doi: 10.1007/BF01744549.
Takayasu arteritis occurs with a strong predilection for women and particular geographic areas, and as related to the etiology of the disease, association of HLA antigens has been suggested. In the present study, the authors investigated the association of Takayasu arteritis with class I and class II HLA antigens in 59 Korean patients with this disease. Increased frequencies of HLA-Bw52 (chi 2 6.213, P < 0.02), Cw6 (chi 2 4.132, P < 0.05), DR7 (chi 2 4.506, P < 0.04), and DQw2 (chi 2 7.327, P < 0.01) were observed in the patient group as compared to the control group of healthy Koreans. In the Korean population, 2 risk factors in the HLA system for developing this disease appear to be (1) Bw52 and (2) DR7 and a probable haplotype of Cw6, B13, DR7, DQw2. Previous studies of the Japanese population revealed association of Bw52 and class II HLA antigens (DR2, Dw12), which are in linkage disequilibrium with Bw52. It is of interest that in the Korean population, class II antigens (DR7, DQw2), which are not linked to BW52, are associated with the disease. This finding suggests that the disease susceptibility gene of Takayasu arteritis is located between the HLA-B locus and HLA-DR, DQ loci.
高安动脉炎在女性和特定地理区域中具有很强的发病倾向，并且关于该疾病的病因，有人提出了HLA抗原的关联性。在本研究中，作者调查了59例韩国高安动脉炎患者中I类和II类HLA抗原与高安动脉炎的关联性。与韩国健康对照组相比，患者组中HLA - Bw52（卡方值6.213，P < 0.02）、Cw6（卡方值4.132，P < 0.05）、DR7（卡方值4.506，P < 0.04）和DQw2（卡方值7.327，P < 0.01）的频率增加。在韩国人群中，HLA系统中与患此病相关的两个风险因素似乎是（1）Bw52和（2）DR7以及可能的单倍型Cw6、B13、DR7、DQw2。先前对日本人群的研究揭示了Bw52与II类HLA抗原（DR2、Dw12）的关联性，它们与Bw52处于连锁不平衡状态。有趣的是，在韩国人群中，与Bw52不连锁的II类抗原（DR7、DQw2）与该疾病相关。这一发现表明，高安动脉炎的疾病易感基因位于HLA - B位点和HLA - DR、DQ位点之间。
