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关于小鼠皮肤肿瘤发生的生化机制。VII. 肿瘤启动剂对3H-胆碱和3H-甘油掺入小鼠表皮磷脂酰胆碱的影响及其与对3H-胸腺嘧啶核苷掺入DNA的影响的关系。

On the biochemical mechanism of tumorigenesis in mouse skin. VII. The effects of tumor promoters on 3H-choline and 3H-glycerol incorporation into mouse epidermal phosphatidylcholine in relation to their effects on 3H-thymidine incorporation into DNA.

作者信息

Balmain A, Hecker E

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Aug 30;86(3):251-61. doi: 10.1007/BF00286944.

DOI:10.1007/BF00286944
PMID:136100
Abstract

The kinetics of the stimulation of phospholipid and DNA biosynthesis in mouse epidermis after treatment with various tumor promoting agents has been investigated. 3H-choline and 3H-glycerol were used as precursors for phosphatidylcholine. An early stimulation of 3H-choline incorporation into phosphatidylcholine is observed which always precedes the stimulation of 3H-thymidine incorporation into epidermal DNA. This is interpreted as being a manifestation of the proliferation of cellular membranes in preparation for cell division. Appreciable differences are observed in the incorporation of 3H-choline and 3H-glycerol into phosphatidylcholine, the possible reasons for which are discussed. It is concluded that 3H-choline incorporation is a more reliable parameter for the measurement of phosphatidylcholine biosynthesis than 3H-glycerol incorporation. The relationship between those effects on phospholipid synthesis and the tumor promoting activity of the substances tested is discussed.

摘要

研究了用各种促癌剂处理后小鼠表皮中磷脂和DNA生物合成的刺激动力学。3H-胆碱和3H-甘油用作磷脂酰胆碱的前体。观察到3H-胆碱掺入磷脂酰胆碱的早期刺激，其总是先于3H-胸苷掺入表皮DNA的刺激。这被解释为是为细胞分裂做准备的细胞膜增殖的一种表现。在3H-胆碱和3H-甘油掺入磷脂酰胆碱方面观察到明显差异，并讨论了其可能的原因。得出结论，与3H-甘油掺入相比，3H-胆碱掺入是测量磷脂酰胆碱生物合成更可靠的参数。讨论了这些对磷脂合成的影响与所测试物质的促癌活性之间的关系。

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1
On the biochemical mechanism of tumorigenesis in mouse skin. VII. The effects of tumor promoters on 3H-choline and 3H-glycerol incorporation into mouse epidermal phosphatidylcholine in relation to their effects on 3H-thymidine incorporation into DNA.关于小鼠皮肤肿瘤发生的生化机制。VII. 肿瘤启动剂对3H-胆碱和3H-甘油掺入小鼠表皮磷脂酰胆碱的影响及其与对3H-胸腺嘧啶核苷掺入DNA的影响的关系。
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引用本文的文献

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Host defense mechanisms against tumors as the principal targets of tumor promoters.作为肿瘤促进剂主要靶点的宿主抗肿瘤防御机制。
J Cancer Res Clin Oncol. 1983;105(3):203-11. doi: 10.1007/BF00395747.
2
Induction of differentiation in human promyelocytic leukemia cells by tumor promoters.肿瘤启动子诱导人早幼粒细胞白血病细胞分化
J Cancer Res Clin Oncol. 1982;103(1):17-29. doi: 10.1007/BF00410302.
3
Effects of the phorbolester TPA and of the ionophore A 23187 on phospholipase A2 and C activities in the mouse epidermal cell line HEL-30.

本文引用的文献

1
Biosynthesis of phospholipides.磷脂的生物合成。
Fed Proc. 1957 Sep;16(3):847-53.
2
The use of radioactive choline as a label for microsomal membranes. I. Selectivity of label for endoplasmic reticulum and specificity for lecithin.放射性胆碱作为微粒体膜标记物的应用。I. 对内质网标记的选择性及对卵磷脂的特异性
Biochim Biophys Acta. 1968 Sep 17;163(2):218-25. doi: 10.1016/0005-2736(68)90100-4.
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Tumor-promoting activity of phorbol and four diesters of phorbol in mouse skin.佛波醇及其四种二酯在小鼠皮肤中的促肿瘤活性。
佛波酯TPA和离子载体A 23187对小鼠表皮细胞系HEL-30中磷脂酶A2和C活性的影响。
J Cancer Res Clin Oncol. 1987;113(4):310-8. doi: 10.1007/BF00397714.
4
[Co-carcinogens or modulators of carcinogenesis. New aspects of the etiology of human tumors and of the molecular mechanisms of carcinogenesis].[致癌协同剂或致癌作用调节剂。人类肿瘤病因学及致癌分子机制的新进展]
Naturwissenschaften. 1978 Dec;65(12):640-8. doi: 10.1007/BF00401906.
Cancer Res. 1971 Aug;31(8):1074-9.
4
Effects of phorbol and four diesters of phorbol on the incorporation of tritiated precursors into DNA, RNA, and protein in mouse epidermis.佛波醇及佛波醇的四种二酯对氚标记前体掺入小鼠表皮DNA、RNA和蛋白质的影响。
Cancer Res. 1971 Oct;31(10):1434-9.
5
Early estrogen effects on lipid metabolism in rat uterus.早期雌激素对大鼠子宫脂质代谢的影响。
Endocrinology. 1972 Nov;91(5):1273-83. doi: 10.1210/endo-91-5-1273.
6
The stimulation of phospholipid metabolism in mouse skin following phorbol ester treatment.佛波酯处理后小鼠皮肤中磷脂代谢的刺激作用。
Biochim Biophys Acta. 1972 Sep 7;280(1):57-70. doi: 10.1016/0005-2760(72)90212-3.
7
Acrylamide gel electrophoresis studies of the incorporation of cytidine- 3 H into mouse skin RNA at early times after treatment with phorbol esters.在用佛波酯处理后的早期，对3H-胞苷掺入小鼠皮肤RNA的丙烯酰胺凝胶电泳研究。
Cancer Res. 1972 Apr;32(4):781-8.
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[Morphological studies on the hyperplasiogenic effect of the biologically active phorbol ester A1].[关于具有生物活性的佛波醇酯A1促增生作用的形态学研究]
Virchows Arch B Cell Pathol. 1971;8(3):196-205.
9
The early stimulation of phospholipid metabolism by 12-0-tetradecanoyl-phorbol-13-acetate and its specificity for tumor promotion.12-0-十四烷酰佛波醇-13-乙酸酯对磷脂代谢的早期刺激作用及其对肿瘤促进的特异性。
Cancer Res. 1973 Aug;33(8):1945-52.
10
Measurement of lipid synthesis in mouse auricular skin cultured in vitro.体外培养的小鼠耳廓皮肤脂质合成的测量。
Br J Dermatol. 1972 Nov;87(5):475-95. doi: 10.1111/j.1365-2133.1972.tb01596.x.