通过二维位移相关氢核磁共振波谱法对大鼠脑葡萄糖变化进行体内鉴定和监测。

In vivo identification and monitoring of changes in rat brain glucose by two-dimensional shift-correlated 1H NMR spectroscopy.

作者信息

Peres M, Fedeli O, Barrere B, Gillet B, Berenger G, Seylaz J, Beloeil J C

机构信息

Institut de Chimie des Substances Naturelles C.N.R.S., Gif sur Yvette, France.

出版信息

Magn Reson Med. 1992 Oct;27(2):356-61. doi: 10.1002/mrm.1910270216.

DOI:10.1002/mrm.1910270216

PMID:1361021

Abstract

Intracerebral glucose resonance was directly detected and resolved in vivo by two-dimensional shift-correlated (COSY) 1H NMR spectroscopy in anesthetized rats (n = 4). The relative changes in brain glucose concentration were measured by volume integration of the alpha-D-glucose cross peak in the 2D COSY spectra. This report demonstrates the possibility of monitoring the variations in cerebral glucose following iv injection of glucose.

摘要

在麻醉大鼠（n = 4）中，通过二维位移相关（COSY）1H核磁共振光谱在体内直接检测并解析了脑内葡萄糖共振。通过二维COSY光谱中α-D-葡萄糖交叉峰的体积积分来测量脑葡萄糖浓度的相对变化。本报告证明了静脉注射葡萄糖后监测脑葡萄糖变化的可能性。