抗原-抗体相互作用对血液凝固的影响。
An effect of antigen-antibody interaction on blood coagulation.
作者信息
ROBBINS J, STETSON C A
出版信息
J Exp Med. 1959 Jan 1;109(1):1-8. doi: 10.1084/jem.109.1.1.
Abstract
Each of several antigen-antibody systems studied has been found to affect the coagulation mechanism in the rabbit, causing a marked shortening of the coagulation time in vitro of samples of whole blood maintained in siliconized glassware. Addition of specific antigen to the blood of actively immunized animals or addition of antigen-antibody mixtures to the blood of normal animals produced the effect. The coagulation time of plasma was not affected, indicating that the phenomenon may be mediated by an effect on platelets. This effect of antigen-antibody interaction may be involved in the production of tissue damage in vivo.
摘要
在所研究的几个抗原 - 抗体系统中，每个系统都已被发现会影响兔子的凝血机制，导致保存在硅化玻璃器皿中的全血样本在体外的凝血时间显著缩短。向主动免疫动物的血液中添加特异性抗原，或向正常动物的血液中添加抗原 - 抗体混合物，都会产生这种效果。血浆的凝血时间不受影响，这表明该现象可能是由对血小板的作用介导的。抗原 - 抗体相互作用的这种效应可能参与了体内组织损伤的产生。
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