HOROWITZ H I, DES PREZ R M, HOOK E W
J Exp Med. 1962 Nov 1;116(5):619-33. doi: 10.1084/jem.116.5.619.
Incubation of rabbit platelet-rich plasma with bacterial endotoxin results in activation of platelet factor 3, a precursor of blood thromboplastin. This platelet-endotoxin interaction is dose- and temperature-dependent, and is similar to the effects of antigen-antibody union in the presence of platelets. Injection of endotoxin intravenously is associated with a transient increase in platelet factor 3. Since platelet factor 3 can be demonstrated in platelet-poor plasma as well as platelet-rich plasma after endotoxin injection, it seems likely that an actual transfer of factor 3 from platelets to plasma occurs and that this activity is then rapidly inactivated or cleared from the blood stream.
用细菌内毒素孵育富含血小板的兔血浆会导致血小板因子3（血液凝血致活酶的前体）的激活。这种血小板与内毒素的相互作用是剂量和温度依赖性的，并且类似于在血小板存在下抗原 - 抗体结合的效应。静脉注射内毒素与血小板因子3的短暂增加有关。由于在内毒素注射后，血小板因子3在贫血小板血浆以及富含血小板的血浆中均能被检测到，似乎很可能发生了因子3从血小板到血浆的实际转移，并且这种活性随后迅速从血流中失活或清除。
