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[ACTIVATION OF BLOOD COAGULATION BY A BACTERIAL ENDOTOXIN IN PERSONS UNDER COUMARIN THERAPY].[香豆素治疗患者中细菌内毒素对血液凝固的激活作用]
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Studies on the mechanism of the Shwartzman phenomenon; certain factors involved in the production of the local hemorrhagic necrosis.施瓦茨曼现象的机制研究；局部出血性坏死产生过程中的某些相关因素。
J Exp Med. 1951 May;93(5):489-504. doi: 10.1084/jem.93.5.489.
2
Pulmonary vascular effects of serotonin (5-OH-tryptamine) in dogs: its role in causing pulmonary edema.血清素（5-羟色胺）对犬肺血管的影响：其在导致肺水肿中的作用。
Am J Physiol. 1959 Nov;197:955-8. doi: 10.1152/ajplegacy.1959.197.5.955.
3
The release of histamine and 5-hydroxytryptamine (serotonin) from platelets by antigen-antibody reactions (in vitro).抗原-抗体反应（体外）导致血小板释放组胺和5-羟色胺（血清素）。
J Physiol. 1955 Apr 28;128(1):9-27. doi: 10.1113/jphysiol.1955.sp005289.
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Mechanisms of the hemodynamic effects of endotoxin.内毒素血流动力学效应的机制。
Physiol Rev. 1960 Apr;40:245-79. doi: 10.1152/physrev.1960.40.2.245.
5
Immediate effects of intravenous endotoxin on serotonin concentrations and blood platelets.静脉内注入内毒素对血清素浓度和血小板的即时影响。
Circ Res. 1960 Jan;8:234-9. doi: 10.1161/01.res.8.1.234.
6
Cellular source and charcter of a heatstable bactericidal property associated with rabbit and rat platelets.与兔和大鼠血小板相关的一种热稳定杀菌特性的细胞来源及特征
J Exp Med. 1961 Apr 1;113(4):701-11. doi: 10.1084/jem.113.4.701.
7
Generation of coagulation product I and its interaction with platelets and phospholipids.凝血产物I的生成及其与血小板和磷脂的相互作用。
J Appl Physiol. 1961 Jan;16:112-4. doi: 10.1152/jappl.1961.16.1.112.
8
Comparative bactericidal activities of blood serum and plasma serum.血清与血浆血清的杀菌活性比较
J Exp Med. 1960 Jul 1;112(1):15-22. doi: 10.1084/jem.112.1.15.
9
The release of histamine from rabbit platelets by means of antigen-antibody precipitates. II. The role of plasma in the release of histamine.通过抗原-抗体沉淀物从兔血小板中释放组胺。II. 血浆在组胺释放中的作用。
J Immunol. 1961 Apr;86:377-81.
10
The release of histamine from rabbit platelets by means of antigen-antibody precipitates. I. The participation of the immune complex in histamine release.通过抗原-抗体沉淀物从兔血小板中释放组胺。I. 免疫复合物在组胺释放中的作用。
J Immunol. 1961 Apr;86:369-76.

细菌内毒素对兔血小板的作用。I. 体外血小板聚集及血小板因子的释放

Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro.

作者信息

DES PREZ R M, HOROWITZ H I, HOOK E W

出版信息

J Exp Med. 1961 Dec 1;114(6):857-74. doi: 10.1084/jem.114.6.857.

DOI:10.1084/jem.114.6.857
PMID:13885652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180403/
Abstract

Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37 degrees C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is necessary for the platelet-endotoxin interaction. Additional studies have shown that incubation of endotoxin with platelet-rich rabbit plasma also results in release of platelet phospholipid and bactericidins active against B. subtilis.

摘要

将富含血小板的兔血浆与大肠杆菌内毒素在37℃下孵育会导致血小板聚集以及血小板5-羟色胺转移至血浆中。5-羟色胺的释放受内毒素剂量、抗凝剂类型和孵育温度的影响。一种热不稳定的血浆因子对于血小板-内毒素相互作用是必需的。进一步的研究表明，内毒素与富含血小板的兔血浆孵育还会导致血小板磷脂和对枯草芽孢杆菌有活性的杀菌素的释放。