细菌内毒素对兔血小板的作用。I. 体外血小板聚集及血小板因子的释放
Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro.
作者信息
DES PREZ R M, HOROWITZ H I, HOOK E W
出版信息
J Exp Med. 1961 Dec 1;114(6):857-74. doi: 10.1084/jem.114.6.857.
Abstract
Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37 degrees C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is necessary for the platelet-endotoxin interaction. Additional studies have shown that incubation of endotoxin with platelet-rich rabbit plasma also results in release of platelet phospholipid and bactericidins active against B. subtilis.
摘要
将富含血小板的兔血浆与大肠杆菌内毒素在37℃下孵育会导致血小板聚集以及血小板5-羟色胺转移至血浆中。5-羟色胺的释放受内毒素剂量、抗凝剂类型和孵育温度的影响。一种热不稳定的血浆因子对于血小板-内毒素相互作用是必需的。进一步的研究表明，内毒素与富含血小板的兔血浆孵育还会导致血小板磷脂和对枯草芽孢杆菌有活性的杀菌素的释放。
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