人类白细胞抗原多态性与进化。

HLA polymorphisms and evolution.

作者信息

Riley E, Olerup O

机构信息

Institute of Cell, Animal and Population Biology, University of Edinburgh, UK.

出版信息

Immunol Today. 1992 Sep;13(9):333-5. doi: 10.1016/0167-5699(92)90165-4.

DOI:10.1016/0167-5699(92)90165-4

PMID:1361325

Abstract

Polymorphisms within the human MHC are of interest to immunologists, for their functional significance, and to geneticists, as markers of populations. Here, Eleanor Riley and Olle Olerup describe how molecular analysis of the HLA complex is beginning to reveal the true extent of class II diversity, and demonstrate the use of this information to clarify the historical relationships between different human populations.

摘要

人类主要组织相容性复合体（MHC）中的多态性，因其功能意义受到免疫学家的关注；同时作为群体标记，也受到遗传学家的关注。在此，埃莉诺·赖利和奥勒·奥勒鲁普描述了对人类白细胞抗原（HLA）复合体的分子分析如何开始揭示II类多样性的真实程度，并展示了如何利用这些信息来阐明不同人类群体之间的历史关系。