Funariu G, Turdeanu N, Chirileanu T, Părăian I, Pop F G
Clinica de Chirurgie III, I.M.F. Cluj-Napoca.
Chirurgia (Bucur). 1992;41(1):32-42.
The retrospective analysis of 3 clinical observations points out the etiopathogenetic, clinical and therapeutical aspects of the diffuse stenotic cholangitis, which can occur after the surgical treatment of the hepatic hydatid cyst. Although rare (2.9% of hydatid cysts, 13% of those which communicate with the bile ducts), the diffuse stenotic posthydatid cholangitis represents a severe postoperative complication in cases of median cysts, exerting a compression upon the convergence of hepatic ducts and communicating with the biliary tract. Its presence should be clinically suspected if a mechanical icterus with septic angiocholitis, sometimes associated with an external biliary fistula (from the residual cavity), occurs in the postoperative course of these patients, especially if the primary operation has excluded the remanance of an obstacle at the level of the main bile duct. The lesional substrate is comparable with that of the primitive sclerosing cholangitis, from which it differs through its clear relation with the primary treatment of the hepatic hydatid cyst, through the rapid course of stenotic lesions which, although diffuse, may become more marked in certain segments, as well as through the constant suprastenotic dilatation of the bile ducts. In the pathogenesis are involved the caustic action of some scolicide solutions (2 per cent formaldehyde solution, hypertonic salt solution) on the wall of the bile duct and the cystobiliary communication which predisposes to the peroperative occurrence o-a migration syndrome and of angiocholitis. It requires an early surgical reintervention in order to solve the cholestasis and angiocholitis: according to the morphological situation, we have the choice between disobstruction and trans-stenotic calibration drainage, on the one hand, and biliodigestive derivations in the hilum, which are more efficient, on the other. The prognosis is burdened with the vital risk of septic angiocholitis and with the early occurrence of a secondary biliary cirrhosis or of stenotic recurrences. Prophylaxis consists in the performance of a primary surgical treatment, adequate in median and communicating hydatid cysts, avoiding the "blind" intracystic administration of scolicide solutions, which exert a caustic action on the bile ducts.
对3例临床观察病例的回顾性分析指出了弥漫性狭窄性胆管炎的病因、临床及治疗方面的问题,这种胆管炎可发生于肝包虫囊肿手术后。虽然罕见(占包虫囊肿的2.9%,与胆管相通的囊肿中的13%),但弥漫性狭窄性包虫病后胆管炎在中位囊肿病例中是一种严重的术后并发症,对肝管汇合处产生压迫并与胆道相通。如果这些患者术后出现机械性黄疸伴感染性胆管炎,有时伴有外胆管瘘(来自残留腔),尤其是如果初次手术排除了主胆管水平存在残留梗阻时,临床上应怀疑其存在。病变基础与原发性硬化性胆管炎相似,但不同之处在于它与肝包虫囊肿的初次治疗有明确关系,狭窄病变进展迅速,虽为弥漫性,但在某些节段可能更明显,以及胆管恒定的狭窄上方扩张。发病机制涉及某些杀头节片剂溶液(2%甲醛溶液、高渗盐溶液)对胆管壁的腐蚀作用以及囊肿胆管相通,这易导致术中出现迁移综合征和胆管炎。需要早期手术再次干预以解决胆汁淤积和胆管炎:根据形态情况,一方面我们可以选择解除梗阻和经狭窄校准引流,另一方面可以选择在肝门部进行更有效的胆肠转流术。预后因感染性胆管炎的致命风险以及继发性胆汁性肝硬化或狭窄复发的早期发生而受到影响。预防措施包括进行充分的原发性手术治疗,适用于中位和相通的包虫囊肿,避免“盲目”向囊内注射杀头节片剂溶液,因为其对胆管有腐蚀作用。