N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801可预防丙咪嗪诱导的对喹吡罗的超敏反应。

The NMDA receptor antagonist MK-801 prevents imipramine-induced supersensitivity to quinpirole.

作者信息

D'Aquila P S, Sias A, Gessa G L, Serra G

机构信息

B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.

出版信息

Eur J Pharmacol. 1992 Dec 2;224(2-3):199-202. doi: 10.1016/0014-2999(92)90805-e.

DOI:10.1016/0014-2999(92)90805-e

PMID:1361447

Abstract

Chronic treatment with imipramine enhanced the locomotor stimulant response to quinpirole (0.3 mg/kg s.c.), a dopamine D2/D3 receptor agonist. Chronic, but not acute, blockade of the NMDA receptor with the non-competitive antagonist MK-801 (0.3 mg/kg i.p.) prevented the imipramine-induced potentiation of the quinpirole effect. The results suggest that NMDA receptors play a role in the development of supersensitivity to dopamine receptor agonists produced by chronic antidepressant treatment.

摘要

用丙咪嗪进行长期治疗增强了对喹吡罗（0.3毫克/千克，皮下注射）的运动刺激反应，喹吡罗是一种多巴胺D2/D3受体激动剂。用非竞争性拮抗剂MK-801（0.3毫克/千克，腹腔注射）对NMDA受体进行长期而非急性阻断，可防止丙咪嗪诱导的喹吡罗效应增强。结果表明，NMDA受体在慢性抗抑郁治疗产生的对多巴胺受体激动剂超敏反应的发展中起作用。