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[蒙古居民的遗传分化。蒙古居民中线粒体DNA限制性片段长度多态性和单倍型的地理分布以及线粒体基因组突变率的群体评估]

[Genetic differentiation of the inhabitants of Mongolia. Geographic distribution of mitochondrial DNA RFLPs and mitotypes in the inhabitants of Mongolia and a population assessment of the mutation rate in the mitochondrial genome].

作者信息

Sambuugiĭn R, Rychkov Iu G, Petrishchev V N

出版信息

Genetika. 1992 Oct;28(10):136-53.

PMID:1361477
Abstract

The geographical distribution of the Asian specific deletion--insertion polymorphisms and or the RFLP's in the V noncoding region and the D-loop and of the mitotypes was analysed in Mongolia. The frequencies of the mtDNA markers demonstrated homogeneity of 18 local groups in Mongolia. The geographical distribution of the mitotypes showed the existence of two ancestral maternal lineages in mongols. There was no significant difference in the average FST values between mitochondrial gene flow and the nuclear gene flow of the Mongolian population. The equality of FST values permit to calculate the mutation rate for the human mtDNA--6.10(-9) per nucleotide per year. The data reveals the Mongolian population is in the equilibrium.

摘要

在蒙古国分析了亚洲特异性缺失-插入多态性以及V非编码区、D环的限制性片段长度多态性(RFLP)和线粒体类型的地理分布。线粒体DNA标记的频率表明蒙古国18个当地群体具有同质性。线粒体类型的地理分布显示蒙古人存在两个母系祖先谱系。蒙古人群体的线粒体基因流和核基因流之间的平均FST值没有显著差异。FST值的相等使得能够计算人类线粒体DNA的突变率——每年每核苷酸6.1×10⁻⁹。数据表明蒙古人群体处于平衡状态。

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