Matlystatins, new inhibitors of typeIV collagenases from Actinomadura atramentaria. II. Biological activities.
作者信息
Tanzawa K, Ishii M, Ogita T, Shimada K
机构信息
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1992 Nov;45(11):1733-7. doi: 10.7164/antibiotics.45.1733.
PMID:1361486
Abstract
Matlystatin A, the main component of matlystatins, inhibits 92 kDa and 72 kDa typeIV collagenases with IC50 values of 0.3 microM and 0.56 microM, respectively, while 7- to 11-fold greater concentrations are required to inhibit thermolysin and aminopeptidase M. The inhibition is reversible and competitive with respect to gelatin. It inhibits the invasion of basement membrane Matrigel by human fibrosarcoma HT1080 dose-dependently with an IC50 value of 21.6 microM.
摘要
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