Turto H, Lindy S
Adv Cardiol. 1976;18(0):41-5. doi: 10.1159/000399511.
In cardiac hypertrophy the total content of collagen is increased in the myocardium. The first indicator of the increased activity of connective tissue cells is an increase in the activity of prolyl hydroxylase of the myocardium. This is later followed by an increase in the rate of collagen synthesis and subsequently collagen is accumulated in the myocardium. Digitoxin treatment prevents the hypertrophy and the accumulation of proteins to the myocardium. This effect of digitoxin is, at least partly, explained by a decreased transport of amino acids into the cells, The results emphasize the importance of amino acid supply to the process of hypertrophy.
在心肌肥大时，心肌中胶原蛋白的总含量会增加。结缔组织细胞活性增加的首个指标是心肌中脯氨酰羟化酶活性的增加。随后是胶原蛋白合成速率的增加，胶原蛋白随后在心肌中积累。洋地黄毒苷治疗可防止心肌肥大和蛋白质积累。洋地黄毒苷的这种作用至少部分是由于氨基酸向细胞内的转运减少所致。这些结果强调了氨基酸供应在肥大过程中的重要性。
