Breborowicz A, Wieczorowska K, Knapowski J, Martis L, Serkes K D, Oreopoulos D G
Department of Pathophysiology, Medical Academy Poznan, Poland.
Adv Perit Dial. 1992;8:11-4.
We studied the effect of chronic intraperitoneal (ip) infusion of saline supplemented with the glycosaminoglycan-chondroitin sulphate 0.1% on the permeability and peroxidation of the peritoneal membrane in rats and compared this with the effect of saline infusion alone. Animals treated with chondroitin sulphate had a higher net ultrafiltration (uf), a slower glucose absorption from the dialysate and less trans-peritoneal loss of proteins. Chronic ip infusion of chondroitin sulphate reduced peroxidation of the peritoneum. These observations suggest that chondroitin may effect the peritoneal interstitium-an important barrier of fluid and solutes transport.
我们研究了长期腹腔内注射补充0.1%糖胺聚糖硫酸软骨素的生理盐水对大鼠腹膜通透性和过氧化作用的影响，并将其与单纯注射生理盐水的效果进行比较。接受硫酸软骨素治疗的动物具有更高的净超滤率、透析液中葡萄糖吸收更慢以及腹膜蛋白流失更少。长期腹腔内注射硫酸软骨素可降低腹膜的过氧化作用。这些观察结果表明，硫酸软骨素可能会影响腹膜间质，而腹膜间质是液体和溶质运输的重要屏障。
