Breborowicz A, Wieczorowska K, Martis L, Oreopoulos D G
Department of Pathophysiology, Medical Academy Poznan, Poland.
Nephron. 1994;67(3):346-50. doi: 10.1159/000187991.
We evaluated the effect of 6 days of intraperitoneal saline infusion on peritoneal peroxidation and permeability in rats. Peroxidation of the peritoneum as measured by malondialdehyde concentration in the omentum was increased and there was a concomitant augmented membrane permeability to glucose and resulted in a loss of ultrafiltration. In vitro experiments with mesothelial cells showed that glycosaminoglycan chondroitin sulphate appears to act as a scavenger of free radicals and so protects the mesothelial cells against injury. Thus, in rats, supplementation of the infused saline with chondroitin sulphate reduces peroxidation of the peritoneum and prevents loss of ultrafiltration during peritoneal dialysis. These results suggest that chondroitin sulphate may be effective in preventing the deterioration of peritoneal permeability during chronic peritoneal dialysis. This beneficial effect probably derives from the scavenging of free radicals by chondroitin sulphate.
我们评估了连续6天腹腔内输注生理盐水对大鼠腹膜过氧化和通透性的影响。通过大网膜中丙二醛浓度测定的腹膜过氧化增加，同时腹膜对葡萄糖的通透性增强，导致超滤功能丧失。间皮细胞的体外实验表明，硫酸软骨素糖胺聚糖似乎可作为自由基清除剂，从而保护间皮细胞免受损伤。因此，在大鼠中，向输注的生理盐水中补充硫酸软骨素可减少腹膜过氧化，并防止腹膜透析期间超滤功能丧失。这些结果表明，硫酸软骨素可能有效预防慢性腹膜透析期间腹膜通透性的恶化。这种有益作用可能源于硫酸软骨素对自由基的清除作用。
