Breborowicz A, Radkowski M, Knapowski J, Oreopoulos D G
Department of Pathophysiology, Medical School, Poznan, Poland.
Perit Dial Int. 1991;11(4):351-4.
The effect of chondroitin sulphate (CS) on peritoneal fluid and solute transport was studied in rats undergoing peritoneal dialysis. In the presence of CS, net ultrafiltration increased, while absorption of glucose and horseradish peroxidase from the peritoneal cavity decreased. Albumin, used instead of CS, did not modify either fluid or solute transport. In in vitro experiments on isolated rabbit mesentery, CS decreased transmembrane water flow induced by hydrostatic pressure, and its effect was not fully reversed 60 minutes after "wash-out" of this glycosaminoglycan. We postulate that the polyanionic CS molecules are trapped in the peritoneal interstitium, thus decreasing its hydraulic conductivity and permeability, which in turn increases net fluid removal during peritoneal dialysis because of its slower absorption from the peritoneal cavity.
在接受腹膜透析的大鼠中研究了硫酸软骨素（CS）对腹膜液和溶质转运的影响。在CS存在的情况下，净超滤增加，而腹膜腔中葡萄糖和辣根过氧化物酶的吸收减少。用白蛋白代替CS，对液体或溶质转运均无影响。在离体兔肠系膜的体外实验中，CS降低了静水压诱导的跨膜水流，并且在洗脱这种糖胺聚糖60分钟后其作用未完全逆转。我们推测，带聚阴离子的CS分子被困在腹膜间质中，从而降低其水力传导率和通透性，这反过来又增加了腹膜透析期间的净液体清除，因为其从腹膜腔的吸收较慢。
