雄性和雌性大鼠体内注射的[14C]组胺代谢的差异。
The difference in the metabolism of injected [14C]histamine in male and female rats.
作者信息
WESTLING H
出版信息
Br J Pharmacol Chemother. 1958 Dec;13(4):498-500. doi: 10.1111/j.1476-5381.1958.tb00245.x.
Abstract
[(14)C]Histamine was injected subcutaneously in rats. The urine was collected for 24 hr. and analysed for [(14)C]histamine and its various metabolites. It was found that male rats excreted less unchanged [(14)C]histamine than female ones, the difference between the sexes existing also when the animals were treated with aminoguanidine. The cause of the sexual difference appeared to be that the male rats had a larger capacity to methylate histamine.
摘要
将[¹⁴C]组胺皮下注射到大鼠体内。收集24小时尿液，并分析其中的[¹⁴C]组胺及其各种代谢产物。结果发现，雄性大鼠排泄的未变化的[¹⁴C]组胺比雌性大鼠少，在用氨基胍处理动物时，两性之间也存在差异。这种性别差异的原因似乎是雄性大鼠甲基化组胺的能力更强。
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