一种可滤过因子在成年小鼠中引发白血病的免疫学关系。I. 特异性抗血清对感染性的中和作用。
Immunological relationships of a filterable agent causing a leukemia in adult mice. I. The neutralization of infectivity by specific antiserum.
作者信息
FRIEND C
出版信息
J Exp Med. 1959 Feb 1;109(2):217-28. doi: 10.1084/jem.109.2.217.
Abstract
The antigenic character of a filterable agent which induces leukemia in adult mice has been investigated. Mice and rabbits injected with filtrate yielded sera which specifically neutralized infectivity of the agent. Normal sera, sera from mice with other neoplasms-including leukemias from which no causative agent has as yet been obtained,-and sera from leukemic human beings contained no such neutralizing antibody. A formalinized vaccine prepared from filtrates of leukemic spleens induced a significant degree of immunity against the agent, approximately 80 per cent of the vaccinated mice being immune on challenge with it.
摘要
对一种可滤过因子的抗原特性进行了研究，该因子可在成年小鼠中诱发白血病。给小鼠和兔子注射滤液后产生的血清能特异性中和该因子的感染性。正常血清、来自患有其他肿瘤（包括尚未找到致病因子的白血病）的小鼠的血清以及白血病患者的血清中均不含此类中和抗体。用白血病脾脏滤液制备的甲醛化疫苗可诱导对该因子产生显著程度的免疫力，约80%接种疫苗的小鼠在受到攻击时具有免疫力。
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