Kłoczko J, Mian M, Wojtukiewicz M Z, Babiuch L, Bielawiec M, Galar M
Department of Haematology, Medical Academy, Biastok, Poland.
Haemostasis. 1992;22(6):340-4. doi: 10.1159/000216345.
The synthesis of a number of clotting factors takes place in a hepatocyte. Therefore, measurement of these factors in the blood have proved to be of additional value in the diagnosis and follow-up of liver diseases. In the present study we evaluated protein C level in the plasma of patients with liver cell damage due to chronic alcohol consumption. A decrease in plasma protein C concentration which correlated with clinical performance of the patients was found. Significant correlations between the level of protein C and antithrombin III, one-stage prothrombin time, factors VII and X and some biochemical tests reflecting liver cell damage were also stated. The obtained data indicate that plasma protein C level may constitute a useful marker of hepatocellular disease in alcoholics.
多种凝血因子在肝细胞中合成。因此，检测血液中的这些因子已被证明在肝病的诊断和随访中具有额外价值。在本研究中，我们评估了慢性酒精摄入导致肝细胞损伤患者血浆中的蛋白C水平。发现血浆蛋白C浓度降低与患者的临床表现相关。还指出蛋白C水平与抗凝血酶III、一期凝血酶原时间、因子VII和X以及一些反映肝细胞损伤的生化检测之间存在显著相关性。所获得的数据表明，血浆蛋白C水平可能是酗酒者肝细胞疾病的一个有用标志物。
