酒精性肝病中检测血浆谷氨酰胺和谷氨酸浓度的临床意义

Clinical significance of measuring plasma concentrations of glutamine and glutamate in alcoholic liver diseases.

作者信息

Tominaga T, Suzuki H, Mizuno H, Kouno M, Suzuki M, Kato Y, Sato A, Okabe K, Miyashita M

机构信息

Department of Internal Medicine, St. Marianna University School of Medicine, Yokohama, Japan.

出版信息

Alcohol Alcohol Suppl. 1993;1A:103-9. doi: 10.1093/alcalc/28.supplement_1a.103.

DOI:10.1093/alcalc/28.supplement_1a.103

PMID:7908196

Abstract

We investigated the significance of assaying plasma glutamine and glutamate concentrations in various liver diseases. Comparison was made with an aminogram in non-alcoholic liver disease. In alcoholic liver diseases, the plasma glutamate concentration showed a statistically significant elevation compared to the value in non-alcoholic liver diseases. In contrast, the plasma glutamine concentration was elevated in non-alcoholic liver diseases but showed no elevation in alcoholic liver diseases. The glutamate (Glu)/glutamine (Gln) ratio and plasma gamma-GT level correlated well in patients of alcoholic liver diseases. The Glu/Gln ratio became normal after alcohol abstinence. The results suggest that measuring the plasma concentrations of glutamine and glutamate may be a useful method to estimate the pathophysiological state of patients with alcoholic liver diseases.

摘要

我们研究了检测各种肝脏疾病患者血浆谷氨酰胺和谷氨酸浓度的意义。并与非酒精性肝病患者的肝功能检查结果进行了比较。在酒精性肝病中，血浆谷氨酸浓度与非酒精性肝病相比有统计学意义的升高。相反，非酒精性肝病患者血浆谷氨酰胺浓度升高，而酒精性肝病患者则无升高。酒精性肝病患者的谷氨酸（Glu）/谷氨酰胺（Gln）比值与血浆γ-谷氨酰转移酶水平密切相关。戒酒后Glu/Gln比值恢复正常。结果表明，检测血浆谷氨酰胺和谷氨酸浓度可能是评估酒精性肝病患者病理生理状态的一种有用方法。