Nishimura M, Hasumura Y, Takeuchi J
Gastroenterology. 1980 Apr;78(4):691-5.
Administration of ethanol to healthy subjects as well as those with alcoholic fatty livers has been noted to cause mild elevation of serum enzyme activities and alcoholic hyperlipemia. To see whether this effect is also manifested in alcoholics with advanced liver damage, the serum enzyme activities and lipid content after administration of i.v. ethanol (1.2 g/kg of body wt) over 90 min were compared in 5 alcoholics with hepatic fibrosis and/or alcoholic fatty liver and in 9 patients with alcoholic hepatitis with or without cirrhosis. Disappearance rate of ethanol from the serum was nearly the same in both groups. Serum activities of asparate aminotransferase, mitochondrial isoenzyme of asparate aminotransferase, and ornithine carbamyl transferase, measured at 9 and 12 hr after termination of the i.v. ethanol, were significantly elevated in alcoholics with alcoholic hepatitis (P less than 0.05). They were not elevated in alcoholics with fatty liver. By contrast, hyperlipemic responses, measured as the serum content of triacylglycerol 3 hr after ethanol were significantly greater in alcoholics with fatty liver than in alcoholics with alcoholic hepatitis (P less than 0.05). The observed difference in responses of serum enzyme activities and lipid content after ethanol represents an enhanced susceptibility of patients with alcoholic hepatitis and cirrhosis towards alcohol-induced injury.
已注意到，对健康受试者以及患有酒精性脂肪肝的人给予乙醇会导致血清酶活性轻度升高和酒精性高脂血症。为了观察这种效应在患有晚期肝损伤的酗酒者中是否也会出现，对5例患有肝纤维化和/或酒精性脂肪肝的酗酒者以及9例患有酒精性肝炎（有无肝硬化）的患者在静脉注射乙醇（1.2 g/kg体重）90分钟后，比较了血清酶活性和脂质含量。两组中乙醇从血清中的消失率几乎相同。在静脉注射乙醇结束后9小时和12小时测量的天冬氨酸转氨酶、天冬氨酸转氨酶线粒体同工酶和鸟氨酸氨甲酰转移酶的血清活性，在患有酒精性肝炎的酗酒者中显著升高（P<0.05）。在患有脂肪肝的酗酒者中这些酶活性未升高。相比之下，以乙醇注射后3小时的三酰甘油血清含量衡量的高脂血症反应，在患有脂肪肝的酗酒者中比在患有酒精性肝炎的酗酒者中显著更大（P<0.05）。乙醇注射后血清酶活性和脂质含量反应的观察差异表明，患有酒精性肝炎和肝硬化的患者对酒精诱导损伤的易感性增强。
