正常及糖尿病大鼠肌肉中的3-氧代酸辅酶A转移酶
3-oxo acid coenzyme A-transferase in normal and diabetic rat muscle.
作者信息
Fenselau A, Wallis K
出版信息
Biochem J. 1976 Aug 15;158(2):509-12. doi: 10.1042/bj1580509.
Abstract
The amounts of succinyl-CoA--3-oxo acid CoA-transferase (EC 2.8.3.5) decrease progressively in skeletal muscle in streptozotocin-diabetic rats, reaching after 10 days about 50% of the value in normal rat muscle. Electrofocusing studies indicate the occurrence of partial proteolysis of the enzyme in diabetic muscle. However, several functional parameters relating to acetoacetate utilization, including substrate inhibition, are quite similar for muscle transferase preparations from normal and diseased rats. The development of pathological ketoacidosis is discussed in the light of these observations.
摘要
链脲佐菌素诱导的糖尿病大鼠骨骼肌中琥珀酰辅酶A - 3 - 氧代酸辅酶A转移酶（EC 2.8.3.5）的含量逐渐降低，10天后降至正常大鼠肌肉中该酶含量的约50%。等电聚焦研究表明，糖尿病肌肉中该酶发生了部分蛋白水解。然而，正常和患病大鼠肌肉转移酶制剂中与乙酰乙酸利用相关的几个功能参数，包括底物抑制，非常相似。根据这些观察结果讨论了病理性酮症酸中毒的发生情况。
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