Puchalska Patrycja, Crawford Peter A
Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827, USA.
Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827, USA.
Cell Metab. 2017 Feb 7;25(2):262-284. doi: 10.1016/j.cmet.2016.12.022.
Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and organism performance in varying nutrient states and protect from inflammation and injury in multiple organ systems. Traditionally viewed as metabolic substrates enlisted only in carbohydrate restriction, observations underscore the importance of ketone bodies as vital metabolic and signaling mediators when carbohydrates are abundant. Complementing a repertoire of known therapeutic options for diseases of the nervous system, prospective roles for ketone bodies in cancer have arisen, as have intriguing protective roles in heart and liver, opening therapeutic options in obesity-related and cardiovascular disease. Controversies in ketone metabolism and signaling are discussed to reconcile classical dogma with contemporary observations.
酮体代谢是生理稳态的核心节点。在本综述中，我们讨论了酮体如何发挥离散的精细调节代谢作用，从而在不同营养状态下优化器官和机体功能，并保护多个器官系统免受炎症和损伤。传统观点认为酮体仅在碳水化合物受限的情况下作为代谢底物发挥作用，但现有观察结果强调，即使碳水化合物充足时，酮体作为重要的代谢和信号介质也具有重要意义。除了神经系统疾病的一系列已知治疗选择外，酮体在癌症中的潜在作用也已出现，在心脏和肝脏中也具有引人关注的保护作用，为肥胖相关疾病和心血管疾病开辟了治疗选择。本文还讨论了酮体代谢和信号传导方面的争议，以调和传统理论与当代观察结果。
