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Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.酮体在燃料代谢、信号传导和治疗中的多维作用
Cell Metab. 2017 Feb 7;25(2):262-284. doi: 10.1016/j.cmet.2016.12.022.
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Metabolic and Signaling Roles of Ketone Bodies in Health and Disease.酮体在健康和疾病中的代谢和信号作用。
Annu Rev Nutr. 2021 Oct 11;41:49-77. doi: 10.1146/annurev-nutr-111120-111518.
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Ketones and the Heart: Metabolic Principles and Therapeutic Implications.酮体与心脏：代谢原理与治疗意义。
Circ Res. 2023 Mar 31;132(7):882-898. doi: 10.1161/CIRCRESAHA.123.321872. Epub 2023 Mar 30.
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Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy.酮体在癌症生物学中的多维作用：癌症治疗的新机会。
Pharmacol Res. 2019 Dec;150:104500. doi: 10.1016/j.phrs.2019.104500. Epub 2019 Oct 16.
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Why the diabetic heart is energy inefficient: a ketogenesis and ketolysis perspective.为什么糖尿病患者的心脏能量效率低下：从生酮作用和酮体分解的角度来看。
Am J Physiol Heart Circ Physiol. 2021 Oct 1;321(4):H751-H755. doi: 10.1152/ajpheart.00260.2021. Epub 2021 Sep 17.
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Metabolic Messengers: ketone bodies.代谢信使：酮体。
Nat Metab. 2023 Dec;5(12):2062-2074. doi: 10.1038/s42255-023-00935-3. Epub 2023 Dec 13.
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Ketone bodies as epigenetic modifiers.酮体作为表观遗传修饰物。
Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):260-266. doi: 10.1097/MCO.0000000000000475.
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Ketone bodies in epilepsy.癫痫中的酮体。
J Neurochem. 2012 Apr;121(1):28-35. doi: 10.1111/j.1471-4159.2012.07670.x. Epub 2012 Feb 7.
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The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.热量限制、生酮饮食和酮体的神经保护特性。
Brain Res Rev. 2009 Mar;59(2):293-315. doi: 10.1016/j.brainresrev.2008.09.002. Epub 2008 Sep 25.
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Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States.酮体对细胞生物化学、表观遗传学和代谢组学的调节。生酮饮食在生物体生理和病理状态中的意义。
Nutrients. 2020 Mar 17;12(3):788. doi: 10.3390/nu12030788.
引用本文的文献
1
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells.β-羟基丁酸代谢的另一条途径支持癌细胞中胞质乙酰辅酶A的合成。
Nat Metab. 2025 Sep 8. doi: 10.1038/s42255-025-01366-y.
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Challenges and opportunities of wearable molecular sensors in endocrinology and metabolism.可穿戴分子传感器在内分泌学和代谢领域的挑战与机遇
Nat Rev Endocrinol. 2025 Sep 8. doi: 10.1038/s41574-025-01175-z.
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Salutary Effects of Nutritional Ketosis for the Diseased Human Heart.营养性酮症对患病人类心脏的有益作用。
Curr Atheroscler Rep. 2025 Aug 28;27(1):85. doi: 10.1007/s11883-025-01333-8.
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Targeting HMGCS2: Ketogenesis Suppression Accelerates NAFLD Progression in T2DM Comorbidity, While Cynaroside Ameliorates NASH in Concomitant T2DM.靶向3-羟基-3-甲基戊二酰辅酶A合成酶2：抑制生酮作用会加速2型糖尿病合并症中非酒精性脂肪性肝病的进展，而木犀草苷可改善伴发2型糖尿病的非酒精性脂肪性肝炎。
Biomolecules. 2025 Aug 18;15(8):1181. doi: 10.3390/biom15081181.
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Evaluation of the Metabolomics Profile in Charcot-Marie-Tooth (CMT) Patients: Novel Potential Biomarkers.夏科-马里-图思病（CMT）患者代谢组学特征评估：新型潜在生物标志物
Metabolites. 2025 Aug 1;15(8):520. doi: 10.3390/metabo15080520.
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Ketogenic Metabolism in Neurodegenerative Diseases: Mechanisms of Action and Therapeutic Potential.神经退行性疾病中的生酮代谢：作用机制与治疗潜力
Metabolites. 2025 Jul 31;15(8):508. doi: 10.3390/metabo15080508.
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Investigation and Distinction of Energy Metabolism in Proliferating Hepatocytes and Hepatocellular Carcinoma Cells.增殖性肝细胞与肝癌细胞能量代谢的研究与区分
Cells. 2025 Aug 14;14(16):1254. doi: 10.3390/cells14161254.
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Ketogenic diet ameliorates MASLD via balancing mitochondrial dynamics and improving mitochondrial dysfunction.生酮饮食通过平衡线粒体动力学和改善线粒体功能障碍来改善代谢相关脂肪性肝病。
Nutr Diabetes. 2025 Aug 25;15(1):37. doi: 10.1038/s41387-025-00391-w.
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ACSS2 coupled with KAT7 regulates histone β-hydroxybutyrylation to enhance transcription.ACSS2与KAT7协同调节组蛋白β-羟基丁酰化以增强转录。
Sci Adv. 2025 Aug 15;11(33):eadv8448. doi: 10.1126/sciadv.adv8448.
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Metabolic regulation of immunological aging.免疫衰老的代谢调控
Nat Aging. 2025 Aug;5(8):1425-1440. doi: 10.1038/s43587-025-00921-2. Epub 2025 Aug 14.
本文引用的文献
1
Ketogenesis contributes to intestinal cell differentiation.生酮作用有助于肠道细胞分化。
Cell Death Differ. 2017 Mar;24(3):458-468. doi: 10.1038/cdd.2016.142. Epub 2016 Dec 9.
2
Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy.肿瘤代谢、生酮饮食与β-羟基丁酸：辅助性脑肿瘤治疗的新方法
Front Mol Neurosci. 2016 Nov 16;9:122. doi: 10.3389/fnmol.2016.00122. eCollection 2016.
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Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition.靶向肾脏葡萄糖重吸收以治疗高血糖：SGLT2抑制剂的多效性作用
Diabetologia. 2017 Feb;60(2):215-225. doi: 10.1007/s00125-016-4157-3. Epub 2016 Nov 22.
4
Streptozotocin diabetes increases mRNA expression of ketogenic enzymes in the rat heart.链脲佐菌素糖尿病增加大鼠心脏酮生成酶的 mRNA 表达。
Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):307-312. doi: 10.1016/j.bbagen.2016.11.012. Epub 2016 Nov 11.
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Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity.肿瘤诱导的白细胞介素-6重编程宿主代谢以抑制抗肿瘤免疫。
Cell Metab. 2016 Nov 8;24(5):672-684. doi: 10.1016/j.cmet.2016.10.010.
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HMGCS2 enhances invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer.HMGCS2通过与PPARα直接相互作用来激活结直肠癌和口腔癌中的Src信号，从而增强侵袭和转移能力。
Oncotarget. 2017 Apr 4;8(14):22460-22476. doi: 10.18632/oncotarget.13006.
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GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.癫痫发作和生酮饮食条件下，甘油醛-3-磷酸脱氢酶介导的钠通道Scn1a和Scn3a基因的转录后调控
Neuropharmacology. 2017 Feb;113(Pt A):480-489. doi: 10.1016/j.neuropharm.2016.11.002. Epub 2016 Nov 2.
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The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model.酮体的添加通过恢复 MELAS 细胞模型中的复合物 I 组装来缓解线粒体功能障碍。
Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):284-291. doi: 10.1016/j.bbadis.2016.10.028. Epub 2016 Nov 1.
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Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.脂质重编程代谢以成为组蛋白乙酰化的主要碳源。
Cell Rep. 2016 Nov 1;17(6):1463-1472. doi: 10.1016/j.celrep.2016.10.012.
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3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons.3-羟基丁酸调节能量代谢并诱导大脑皮质神经元中脑源性神经营养因子（BDNF）的表达。
J Neurochem. 2016 Dec;139(5):769-781. doi: 10.1111/jnc.13868. Epub 2016 Nov 14.
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