一个患有非特异性X连锁智力障碍的家族与Xq28的连锁关系。
Linkage to Xq28 in a family with nonspecific X-linked mental retardation.
作者信息
Nordström A M, Penttinen M, von Koskull H
机构信息
Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland.
出版信息
Hum Genet. 1992 Nov;90(3):263-6. doi: 10.1007/BF00220075.
Linkage analysis was performed in a family with nonspecific X-linked mental retardation (MRX). Affected individuals had no clinical characteristics other than mental retardation. Linkage was detected to the marker loci DXS477, DXS465, DXS52, DXS15 and F8C with maximum lod scores of 1.70, 1.32, 2.52, 1.70, and 1.09, respectively (theta = 0.0). The results strongly indicate that the gene for mental retardation in the family studied maps close to DXS52.
对一个患有非特异性X连锁智力迟钝（MRX）的家族进行了连锁分析。除智力迟钝外，受影响个体没有其他临床特征。检测到与标记位点DXS477、DXS465、DXS52、DXS15和F8C连锁，最大lod分数分别为1.70、1.32、2.52、1.70和1.09（θ = 0.0）。结果强烈表明，所研究家族中智力迟钝基因定位于靠近DXS52的位置。
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