Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs.
作者信息
Buckland P R, O'Donovan M C, McGuffin P
机构信息
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
出版信息
Neurosci Lett. 1993 Feb 5;150(1):25-8. doi: 10.1016/0304-3940(93)90099-7.
PMID:8469398
Abstract
We have investigated the effects of antipsychotic drugs on the expression of the two dopamine D2 receptor splicing variants using multiprobe oligonucleotide solution hybridisation. Both long and short mRNA variants were increased in abundance by approximately 2-fold by both haloperidol and loxapine after 32 days drug administration.
摘要
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