Gil-Ad I, Klinger B, Pertzelan A, Erster B, Silbergeld A, Talpaz H, Laron Z
Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical Center, Petah Tiqva, Israel.
J Endocrinol Invest. 1992 Nov;15(10):735-9. doi: 10.1007/BF03347642.
A three-month study of the effect of growth hormone (hGH) therapy (0.1 U/kg/day sc) on plasma levels of GH releasing hormone (GHRH), somatostatin and insulin-like growth factor I (IGF-I) and on the hGH responsiveness to exogenous GHRH was carried out in 32 prepubertal short-stature children with normal GH secretion. Blood samples were collected prior to initiation of therapy, and at 5, 30 and 90 days of onset of therapy, as well as 2 and 90 days after termination of therapy. The nonconventional hGH therapy induced an increase in serum IGF-I levels which lasted as long as therapy was continued. Plasma GHRH levels showed an early transitory decrease after five days of therapy, whereas plasma somatostatin levels were unaltered. A slight suppression in hGH responsiveness to exogenous GHRH was found at 2 but not at 90 days after termination of hGH therapy. It is concluded that nonconventional hGH treatment does not cause permanent changes in physiological hGH secretion.
对32名青春期前身材矮小但生长激素（GH）分泌正常的儿童进行了一项为期三个月的研究，观察生长激素（hGH）疗法（0.1 U/kg/天，皮下注射）对生长激素释放激素（GHRH）、生长抑素和胰岛素样生长因子I（IGF-I）血浆水平的影响，以及hGH对外源性GHRH的反应性。在治疗开始前、治疗开始后5天、30天和90天以及治疗结束后2天和90天采集血样。非常规hGH疗法使血清IGF-I水平升高，只要治疗持续，这种升高就会持续。治疗5天后，血浆GHRH水平出现早期短暂下降，而血浆生长抑素水平未改变。在hGH治疗结束后2天发现hGH对外源性GHRH的反应性略有抑制，但在90天时未发现。结论是，非常规hGH治疗不会引起生理性hGH分泌的永久性变化。
