Rosskamp R, Becker M, Haverkamp F, Thomas B, Brühl S, Klumpp J, Liappis N
Department of Paediatrics, University of Bonn, FRG.
Acta Endocrinol (Copenh). 1987 Dec;116(4):549-54. doi: 10.1530/acta.0.1160549.
Following a mixed meal, plasma levels of GHRH, GH, SRIH and insulin were measured in 7 prepubertal children with constitutional delay of growth and adolescence (CDGA) and in 3 children with proven GH-deficiency which responded to GHRH-injection. In children with CDGA, plasma levels of GHRH increased between 60 and 120 min (10.1 +/- 1.2 ng/l vs 25.5 +/- 4.4 ng/l; P less than 0.01). Although no GH increase occurred in patients with GH-deficiency, their plasma GHRH increases were comparable to those in CDGA children. No time relationship was present between circulating GHRH and GH, SRIH, or insulin, nor was there any correlation between their integrated hormone response areas. Sleep-induced plasma GHRH, GH and SRIH values were determined in 10 prepubertal children with CDGA. Spontaneous variations of plasma GHRH and GH values occurred with no temporal or quantitative relationship. SRIH values did not change during nocturnal sleep. In one child with GH-deficiency, comparable GHRH plasma fluctuations occurred, although GH values were all below 1 microgram/l. Our results support the concept that circulating GHRH does not only represent hypothalamic GHRH, but derives mainly from extrahypothalamic sources, possibly from the gastrointestinal tract.
给7名青春前期体质性生长和青春期延迟（CDGA）儿童及3名经证实的生长激素缺乏且对生长激素释放激素（GHRH）注射有反应的儿童进食混合餐，随后测量其血浆中GHRH、生长激素（GH）、生长抑素（SRIH）和胰岛素的水平。在CDGA儿童中，血浆GHRH水平在60至120分钟之间升高（10.1±1.2纳克/升对25.5±4.4纳克/升；P<0.01）。虽然生长激素缺乏患者的GH没有升高，但其血浆GHRH升高与CDGA儿童相当。循环中的GHRH与GH、SRIH或胰岛素之间不存在时间关系，它们的综合激素反应面积之间也没有相关性。对10名青春前期CDGA儿童测定了睡眠诱导的血浆GHRH、GH和SRIH值。血浆GHRH和GH值的自发变化没有时间或数量关系。夜间睡眠期间SRIH值没有变化。在1名生长激素缺乏儿童中，尽管GH值均低于1微克/升，但血浆GHRH出现了类似的波动。我们的结果支持这样的概念，即循环中的GHRH不仅代表下丘脑的GHRH，而且主要来源于下丘脑外的来源，可能来自胃肠道。
