Woodbury R, Kligman A M
University of Pennsylvania, School of Medicine, Department of Dermatology, Philadelphia 19104-6142.
Acta Derm Venereol. 1992 Nov;72(6):403-6.
The daily application of corticosteroids for 18 days to the dorsal skin of hairless mice resulted in loss of volume of all the cutaneous compartments. The epidermis thinned, sebaceous glands regressed, dermal thickness was reduced, horn-filled cysts shrunk, subcutaneous fat disappeared, and regression of the muscular layer occurred. The magnitude of these changes correlated strongly with the accepted potency ranking of these agents by clinical efficacy. Thus, atrophogenicity predicts anti-inflammatory activity. This model furnishes a simple screening method for assaying corticosteroid activity and for optimizing proprietary formulations.
在无毛小鼠背部皮肤每日应用皮质类固醇18天，导致所有皮肤层体积减少。表皮变薄，皮脂腺退化，真皮厚度减小，充满角蛋白的囊肿缩小，皮下脂肪消失，肌肉层发生退化。这些变化的程度与这些药物根据临床疗效所公认的效价排名密切相关。因此，致萎缩性可预测抗炎活性。该模型为测定皮质类固醇活性和优化专利配方提供了一种简单的筛选方法。
