Woodbury R A, Kligman L H, Woodbury M J, Kligman A M
University of Pennsylvania School of Medicine, Department of Dermatology, Philadelphia.
Acta Derm Venereol. 1994 Jan;74(1):15-7. doi: 10.2340/00015555741517.
A single large dose of UVA induced an intense infiltration of neutrophils into the lower dermis of hairless mouse skin, peaking at 24 h. The ability of 15 name brand topical corticosteroids to suppress this infiltrate was determined. The rank order of suppression correlated with the accepted clinical category of anti-inflammatory potency. This is a rapid screening procedure for assaying the anti-inflammatory activity of new steroids and for optimizing the vehicle.
单次大剂量紫外线A（UVA）可诱导嗜中性粒细胞大量浸润无毛小鼠皮肤的真皮下层，在24小时达到峰值。测定了15种名牌外用皮质类固醇抑制这种浸润的能力。抑制的排序与公认的抗炎效力临床分类相关。这是一种用于测定新类固醇抗炎活性和优化赋形剂的快速筛选程序。
