抗肿瘤药。52. 多辐贝利菊。
Antineoplastic agents. 52. Baileya multiradiata.
作者信息
Pettit G R, Herald C L, Judd G F, Bolliger G, Vanell L D, Lehto E, Pase C P
出版信息
Lloydia. 1978 Jan-Feb;41(1):29-36.
The desert-marigold Baileya multiradiata Harv. and Gray (Compositae) has been found to produce a series of sesquiterpenes that markedly inhibit growth of the murine lymphocytic leukemia P388 and the corresponding in vitro cell line. Separation guided by bioassay led to the isolation of baileyin (1), fastigilins B and C (3a and 2a), radiatin (3b), pleniradin (4a), and the new pseudoguaianolide multiradiatin (2b). The most significant antitumor activity was displayed by fastigilin C (2a) and radiation (3b).
沙漠金盏花Baileya multiradiata Harv. and Gray（菊科）已被发现能产生一系列倍半萜，这些倍半萜能显著抑制小鼠淋巴细胞白血病P388及其相应体外细胞系的生长。通过生物测定引导分离，得到了贝利因（1）、快吉灵B和C（3a和2a）、辐射菌素（3b）、全辐射菌素（4a）以及新的假愈创木烷型倍半萜多辐射菌素（2b）。快吉灵C（2a）和辐射菌素（3b）表现出最显著的抗肿瘤活性。
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