WILSON V J
J Gen Physiol. 1959 Mar 20;42(4):703-13. doi: 10.1085/jgp.42.4.703.
Antidromic volleys in muscle nerves may facilitate monosynaptic reflexes originating from neighboring motoneurons. This facilitation has been studied in spinal cats. It is at its peak with a conditioning-test interval of 20 to 30 msec., and can last 50 to 100 msec. The threshold of facilitation is about the same as that of recurrent inhibition. Both phenomena appear to be activated by stimulation of the large motor axons. The latency of facilitation seems to be longer than that of recurrent inhibition by approximately 1 msec., suggesting the presence of at least one more synaptic delay. Facilitation often follows an inhibition of variable depth and duration. Frequently, however, the facilitation is not preceded by inhibition, and therefore it cannot be a rebound effect. The pharmacological properties of facilitation resemble those of recurrent inhibition. Dihydro-beta-erythroidine(1) partially blocks facilitation; the peak is decreased and occurs earlier, and the duration is shortened. Eserine increases the duration of facilitation and inhibition and sometimes enhances their magnitude. It is concluded that recurrent facilitation is mediated by the cholinergic axon collaterals, and that at least two interneurons are located between collateral and motoneuron. Possible mechanisms of facilitation are discussed.
肌神经中的逆向冲动可能会促进源自相邻运动神经元的单突触反射。这种促进作用已在脊髓猫中进行了研究。在条件刺激与测试刺激的间隔为20至30毫秒时，促进作用达到峰值，并且可以持续50至100毫秒。促进作用的阈值与回返性抑制的阈值大致相同。这两种现象似乎都是由大运动轴突的刺激所激活。促进作用的潜伏期似乎比回返性抑制的潜伏期长约1毫秒，这表明至少还存在一个突触延迟。促进作用常常跟随不同深度和持续时间的抑制作用之后出现。然而，促进作用常常并非在抑制作用之前出现，因此它不可能是一种反弹效应。促进作用的药理学特性与回返性抑制的药理学特性相似。二氢 - β - 刺桐定（1）部分阻断促进作用；峰值降低且出现得更早，持续时间缩短。毒扁豆碱增加促进作用和抑制作用的持续时间，有时还会增强它们的强度。得出的结论是，回返性促进作用是由胆碱能轴突侧支介导的，并且在侧支与运动神经元之间至少有两个中间神经元。文中讨论了促进作用的可能机制。
