WILSON V J, TALBOT W H
J Gen Physiol. 1960 Jan;43(3):495-502. doi: 10.1085/jgp.43.3.495.
The action of cumulative doses of meprobamate on antidromic conditioning has been studied in spinal cats. Recurrent facilitation is greatly reduced or completely abolished by total doses ranging from 210 to 400 mg./kg. The depth of recurrent inhibition is not affected in a consistent manner by meprobamate, but the duration of inhibition is markedly increased in all experiments. This differential action of meprobamate on facilitation and inhibition can be utilized to study conditioning effects consisting of combined inhibition and facilitation. If conditioning starts with an inhibitory phase, variable in duration, followed by facilitation, meprobamate depresses the facilitation and reveals an extended inhibitory curve. Facilitation, however, is not always accompanied by inhibition, since in some cases facilitation is depressed and no inhibition is uncovered. The results of these experiments are discussed in relation to the various types of conditioning that have been produced by antidromic stimulation.
在脊髓猫身上研究了眠尔通累积剂量对抗向性条件作用的影响。总剂量在210至400毫克/千克范围内时，反复易化作用会大幅降低或完全消除。眠尔通对反复抑制的深度没有一致的影响，但在所有实验中抑制的持续时间均显著增加。眠尔通对易化和抑制的这种差异作用可用于研究由抑制和易化相结合组成的条件作用效果。如果条件作用始于持续时间可变的抑制期，随后是易化期，眠尔通会抑制易化作用并显示出延长的抑制曲线。然而，易化作用并不总是伴有抑制作用，因为在某些情况下易化作用受到抑制但未发现抑制作用。结合由逆向刺激产生的各种类型的条件作用，对这些实验结果进行了讨论。
