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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gallucci E, Micelli S

Pharmaco-Biological Department, University of Bari, Italy.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Nov;103(3):593-5. doi: 10.1016/0742-8413(92)90186-b.

In this study we found that insulin mixed with m-cresol, normally used as pharmaceutical preparation, shows an earlier and larger stimulating effect on transepithelial sodium transport than insulin alone. 2. The action displayed by the m-cresol seems to be specific for insulin because m-cresol mixed with ADH, a hormone known to stimulate sodium transport, failed to show the potentiation seen for insulin. 3. It is proposed that m-cresol could facilitate the interaction with its receptor by modifying the insulin molecule. 4. This finding could be of biological and pharmacological importance.

在本研究中，我们发现，通常用作药物制剂的与间甲酚混合的胰岛素，对跨上皮钠转运的刺激作用比单独使用胰岛素出现得更早且更强。2. 间甲酚所显示的作用似乎对胰岛素具有特异性，因为与已知可刺激钠转运的激素抗利尿激素混合的间甲酚未能显示出对胰岛素所见的增强作用。3. 有人提出，间甲酚可能通过修饰胰岛素分子来促进其与受体的相互作用。4. 这一发现可能具有生物学和药理学重要性。

Gallucci E, Micelli S

Pharmaco-Biological Department, University of Bari, Italy.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Nov;103(3):593-5. doi: 10.1016/0742-8413(92)90186-b.

In this study we found that insulin mixed with m-cresol, normally used as pharmaceutical preparation, shows an earlier and larger stimulating effect on transepithelial sodium transport than insulin alone. 2. The action displayed by the m-cresol seems to be specific for insulin because m-cresol mixed with ADH, a hormone known to stimulate sodium transport, failed to show the potentiation seen for insulin. 3. It is proposed that m-cresol could facilitate the interaction with its receptor by modifying the insulin molecule. 4. This finding could be of biological and pharmacological importance.

在本研究中，我们发现，通常用作药物制剂的与间甲酚混合的胰岛素，对跨上皮钠转运的刺激作用比单独使用胰岛素出现得更早且更强。2. 间甲酚所显示的作用似乎对胰岛素具有特异性，因为与已知可刺激钠转运的激素抗利尿激素混合的间甲酚未能显示出对胰岛素所见的增强作用。3. 有人提出，间甲酚可能通过修饰胰岛素分子来促进其与受体的相互作用。4. 这一发现可能具有生物学和药理学重要性。