Oke A F, Putz C, Adams R N, Bird E D
Department of Chemistry, University of Kansas, Lawrence 66045.
Psychiatry Res. 1992 Dec;45(4):203-8. doi: 10.1016/0925-4927(92)90015-v.
Previous studies have indicated a marked increase in the dopamine/norepinephrine ratio in thalami of schizophrenic patients compared with those of control subjects. Since these results all came from patients who were receiving neuroleptic drugs, the possibility exists that the increased dopamine concentrations are an effect of medication. To address this question, similar analyses were done on thalami from Huntington's Disease patients who had received neuroleptic treatment. The results showed no differences between the thalami of Huntington's Disease patients and controls, strongly suggesting that chronic treatment with neuroleptic drugs does not result in an increase of endogenous dopamine in the thalami of human subjects.
先前的研究表明，与对照组相比，精神分裂症患者丘脑的多巴胺/去甲肾上腺素比值显著升高。由于这些结果均来自正在接受抗精神病药物治疗的患者，因此存在多巴胺浓度升高是药物作用的可能性。为了解决这个问题，对接受过抗精神病治疗的亨廷顿舞蹈症患者的丘脑进行了类似分析。结果显示，亨廷顿舞蹈症患者和对照组的丘脑之间没有差异，这有力地表明，抗精神病药物的长期治疗不会导致人体丘脑内源性多巴胺增加。
