• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用H3标记的氨基酸进行放射自显影显示，细胞核中存在连续的蛋白质合成。

Continuous protein synthesis in nuclei, shown by radioautography with H3-labeled amino acids.

作者信息

CARNEIRO J, LEBLOND C P

出版信息

Science. 1959 Feb 13;129(3346):391-2. doi: 10.1126/science.129.3346.391.

DOI:10.1126/science.129.3346.391
PMID:13634984
Abstract

Radioautographic investigation of the cell nuclei of adult mice after injection of leucine-H(3), methionine-H(3), or glycine-H(3) shows a high uptake of tritium by chromatin material but not by nucleoli. It is concluded that protein synthesis occurs continuously within nuclear chromatin.

摘要

对注射了氚标记亮氨酸-H(3)、甲硫氨酸-H(3)或甘氨酸-H(3)的成年小鼠细胞核进行放射自显影研究显示，染色质物质对氚的摄取量很高，而核仁则没有。由此得出结论，蛋白质合成在核染色质中持续发生。

相似文献

1
Continuous protein synthesis in nuclei, shown by radioautography with H3-labeled amino acids.用H3标记的氨基酸进行放射自显影显示，细胞核中存在连续的蛋白质合成。
Science. 1959 Feb 13;129(3346):391-2. doi: 10.1126/science.129.3346.391.
2
METHODS FOR THE PURIFICATION OF THYMUS NUCLEI AND THEIR APPLICATION TO STUDIES OF NUCLEAR PROTEIN SYNTHESIS.胸腺细胞核的纯化方法及其在核蛋白合成研究中的应用。
J Cell Biol. 1964 May;21(2):213-31. doi: 10.1083/jcb.21.2.213.
3
[Radioautographic studies with 12 H3 and 5 C14 labelled amino acids of the extent of nuclear and cytoplasmic protein metabolism in various cells from mice and rats].[用12种H3和5种C14标记氨基酸对小鼠和大鼠不同细胞中核蛋白和细胞质蛋白代谢程度进行的放射自显影研究]
Z Zellforsch Mikrosk Anat. 1966;70(4):419-48.
4
[Autoradiographic study on the problem of protein synthesis within the nucleus and cytoplasm of the cell (Study with tritium-labelled leucine, S-35-labelled and C-14-labelled amino acids)].[细胞细胞核与细胞质内蛋白质合成问题的放射自显影研究（用氚标记的亮氨酸、S-35标记和C-14标记的氨基酸进行的研究）]
Beitr Pathol Anat. 1960;122:289-312.
5
RADIOAUTOGRAPHIC RNA AND PROTEIN LABELING AND THE NUCLEOLAR VOLUME IN RATS FOLLOWING ADMINISTRATION OF MODERATE DOSES OF ACTINOMYCIN D.中等剂量放线菌素D给药后大鼠的放射自显影RNA和蛋白质标记及核仁体积
Exp Cell Res. 1964 Nov;36:242-55. doi: 10.1016/0014-4827(64)90205-8.
6
AUTORADIOGRAPHIC EVIDENCE OF A NUCLEAR HISTONE SYNTHESIS DURING MOUSE SPERMIOGENESIS IN THE ABSENCE OF DETECTABLE QUANTITIES OF NUCLEAR RIBONUCLEIC ACID.在未检测到细胞核核糖核酸的情况下，小鼠精子发生过程中细胞核组蛋白合成的放射自显影证据。
Exp Cell Res. 1964 Dec;36:683-8. doi: 10.1016/0014-4827(64)90326-x.
7
[Renewal of proteins in the interphasic nucleus. Radioautographic studies in electron microscopy].[间期细胞核中蛋白质的更新。电子显微镜放射自显影研究]
C R Acad Hebd Seances Acad Sci D. 1970 Oct 28;271(17):1593-6.
8
THYROXINE ADMINISTRATION AND THE UPTAKE OF AMINO ACIDS BY LIVER CELL NUCLEOLUS, NUCLEUS, AND CYTOPLASM, AND BY OTHER CELL TYPES.甲状腺素的给药以及肝细胞核仁、细胞核、细胞质和其他细胞类型对氨基酸的摄取。
Experientia. 1963 Aug 15;19:399-400. doi: 10.1007/BF02171507.
9
INTRANUCLEAR SITE OF HISTONE SYNTHESIS.组蛋白合成的核内位点。
Science. 1964 Sep 25;145(3639):1435-7. doi: 10.1126/science.145.3639.1435.
10
Distribution of radioactivity among total myelin protein amino acids following administration of labeled glycine, leucine, or methionine.给予标记的甘氨酸、亮氨酸或蛋氨酸后，放射性在总髓鞘蛋白氨基酸中的分布。
J Neurosci Res. 1983;10(3):289-94. doi: 10.1002/jnr.490100307.

引用本文的文献

1
Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors.翻译 DRiPs：MHC Ⅰ类对病原体和肿瘤的免疫监视
J Leukoc Biol. 2014 Apr;95(4):551-62. doi: 10.1189/jlb.1113599. Epub 2014 Feb 14.
2
THYROXINE ADMINISTRATION AND THE UPTAKE OF AMINO ACIDS BY LIVER CELL NUCLEOLUS, NUCLEUS, AND CYTOPLASM, AND BY OTHER CELL TYPES.甲状腺素的给药以及肝细胞核仁、细胞核、细胞质和其他细胞类型对氨基酸的摄取。
Experientia. 1963 Aug 15;19:399-400. doi: 10.1007/BF02171507.
3
[The size of the nucleolus- and the nucleolus-karyoplasma relation as an expression of synthetic activities. Autoradiographic studies on liver cells of normal and thioacetamide-treated rats].
[核仁大小及核仁与核质的关系作为合成活性的一种表现。对正常及硫代乙酰胺处理大鼠肝细胞的放射自显影研究]
Z Krebsforsch. 1963;65:351-77.
4
Radioautographic studies with methionine-3H and cytidine-3H in protein-fed, protein-deprived and starved rats.用3H-蛋氨酸和3H-胞嘧啶核苷对蛋白质喂养、蛋白质缺乏和饥饿大鼠进行放射自显影研究。
Z Zellforsch Mikrosk Anat. 1962;58:107-24. doi: 10.1007/BF00406945.
5
Protein synthesis by isolated pea nucleoli.豌豆离体核仁的蛋白质合成
J Cell Biol. 1963 Jul;18(1):41-50. doi: 10.1083/jcb.18.1.41.