Chu T S, Wu M S, Chen Y M, Wu K D
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
J Formos Med Assoc. 1992 Dec;91 Suppl 4:S288-92.
The antihypertensive and metabolic responses to delapril and captopril in hypertensive patients were studied. Forty-six hypertensive patients entered the study and were divided into two groups. The delapril group included 21 essential hypertensive and five renoparenchymal hypertensive patients; while the captopril group included 11 essential hypertensive and nine renoparenchymal hypertensive patients. The patients in the delapril group took delapril 7.5 mg twice a day for 2 weeks. If the antihypertensive effect was inadequate, the dose was increased to 15mg twice a day, and then to 30mg twice a day. The period of delapril treatment was 12 weeks. The patients in the captopril group took captopril 25 mg twice a day or three times a day for 12 weeks. After delapril treatment, there were significant decreases in the systolic (from 163 +/- 17 to 141 +/- 15 mmHg) and diastolic blood pressure (from 105 +/- 13 to 91 +/- 10 mmHg). There were also significant decreases in the systolic (from 161 +/- 18 to 141 +/- 24 mmHg) and diastolic blood pressure (from 100 +/- 10 to 90 +/- 12 mmHg) after captopril treatment (p < 0.001). The pulse rates in both groups showed no significant changes after treatment. The laboratory data in both groups showed few changes after treatment. Plasma renin activity increased after delapril treatment. A cough was the side effect most commonly seen. We conclude that hypertensive patients have the same blood pressure and metabolic responses to delapril as captopril.
研究了高血压患者对地拉普利和卡托普利的降压及代谢反应。46例高血压患者进入该研究并被分为两组。地拉普利组包括21例原发性高血压患者和5例肾实质性高血压患者；而卡托普利组包括11例原发性高血压患者和9例肾实质性高血压患者。地拉普利组患者每日两次服用7.5mg地拉普利，共2周。如果降压效果不佳，剂量增加至每日两次15mg，然后增至每日两次30mg。地拉普利治疗期为12周。卡托普利组患者每日两次或三次服用25mg卡托普利，共12周。地拉普利治疗后，收缩压（从163±17降至141±15mmHg）和舒张压（从105±13降至91±10mmHg）显著降低。卡托普利治疗后，收缩压（从161±18降至141±24mmHg）和舒张压（从100±10降至90±12mmHg）也显著降低（p<0.001）。两组患者治疗后的脉搏率均无显著变化。两组的实验室数据治疗后变化很少。地拉普利治疗后血浆肾素活性增加。咳嗽是最常见的副作用。我们得出结论，高血压患者对地拉普利和卡托普利的血压及代谢反应相同。
