[State of the pancreatic insular apparatus in experimental diabetes mellitus with varying degrees of severity in the rat].

The interrelationship between endocrine cells of the Langerhans islands in experimental diabetes provoked in female Wistar rats are studied. The content of the insulin in B-cells, glucagon in A-cells and somatostatin in D-cells was determined by method of indirect immunofluorescence with the use of monoclonal antibodies and antiserum. It is established that an decrease of the insulin content in B-cells is followed by an increase of glucagon in A-cells and that of somatostatin in D-cells. The increase of the glucagon content is proportional to glycemia level and to the decrease of the insulin in B-cells.