Kolesnyk Iu M, Orestenko Iu M, Abramov A V
Fiziol Zh (1978). 1992 Nov-Dec;38(6):30-6.
Daily hypoxia (6 h, 6000 m) changed the functional state of endocrine pancrease of male and female Wistar rats. The actions of hypoxia on functional state of supraoptic (SO) and paraventricular (PV) nuclei of hypothalamus and islet cells of endocrine pancreas were examined using immunocytochemical, histochemical, morphometric and radioimmunoassay methods. Increase of insulin biosynthesis in beta cells and glucagon secretion of alpha cells, and decrease of the somatostatin contents in delta cells of pancrease islets have been investigated. The functional activity of vasopressinergic magnocellular subnucleus of PV increased, but that of SO decreased with reduction of vasopressin blood concentration at the same time. The functional state of oxytocin synthesis subdivisions of PV and SO were sex dependent, but the oxytocin contents in median eminence increased.
每日低氧（6小时，6000米）改变了雄性和雌性Wistar大鼠内分泌胰腺的功能状态。采用免疫细胞化学、组织化学、形态计量学和放射免疫分析方法，研究了低氧对下丘脑视上核（SO）和室旁核（PV）以及内分泌胰腺胰岛细胞功能状态的影响。研究了胰岛β细胞中胰岛素生物合成的增加、α细胞中胰高血糖素的分泌以及胰岛δ细胞中生长抑素含量的减少。PV的血管加压素能大细胞亚核的功能活性增加，而SO的功能活性降低，同时血液中血管加压素浓度降低。PV和SO的催产素合成亚区的功能状态存在性别差异，但正中隆起处的催产素含量增加。
