Mitrová E, Mayer V
Acta Virol. 1976 Dec;20(6):479-85.
The depressive effect of trifluoperazine (TFP), a phenothiazine derivative, on the morphology of the development of immune response (IR) (humoral and cell-mediated component) was studied in mice given tick-borne encephalitis (TBE) virus, sheep red blood cells (SRBC) or the BCG vaccine. This effect was manifested by a decrease in the mitotic activity of lymphocytes and in the number of blastic transformations after antigenic stimulation. In virus-infected and TFP-given mice, lowered levels of specific virus neutralizing antibody (VNA), together with a pronounced reduction of the inflammatory response in the brain were found. No signs of cytotoxicity following administration of the drug were observed. The mechanism of the immunodepressive action of TFP are discussed.
研究了吩噻嗪衍生物三氟拉嗪（TFP）对感染蜱传脑炎（TBE）病毒、绵羊红细胞（SRBC）或卡介苗疫苗的小鼠免疫反应（IR）（体液和细胞介导成分）发育形态的抑制作用。这种作用表现为淋巴细胞有丝分裂活性降低以及抗原刺激后母细胞转化数量减少。在病毒感染且给予TFP的小鼠中，发现特异性病毒中和抗体（VNA）水平降低，同时大脑中的炎症反应明显减弱。未观察到给药后药物的细胞毒性迹象。讨论了TFP免疫抑制作用的机制。
