Wrońska D, Niezgoda J, Pierzchała K, Sechman A, Bobek S, Hamid A B
Katedra Fizjologii Zwierzat Akademii Rolniczej, Krakowie.
Endokrynol Pol. 1991;42(4):567-74.
The study was aimed at the evaluation of propiopromazine (Combelen, Bayer), a derivative of phenothiazine, as an agent lowering in sheep the response to stress. The stress of emotional origin was induced in sheep by the isolation from herd lasting 1 hour. The isolation experiments were repeated 6 times on the same group of sheep, first three isolations (1-3) in daily intervals and next three (4-6) in weekly intervals. Propiopromazine was administered before each isolation experiment. The reaction of sheep to the isolation stress was weaker after propiopromazine administration. This was suggested by smaller increase in blood serum cortisol and glucose levels when compared to sheep subjected to isolation but not receiving the drug. Such effect was especially conspicuous during the course of the first isolation experiment; during the next experiments the difference concerning the reaction to stress between the sheep isolated from the herd receiving and not receiving the drug was gradually diminishing. It was shown in addition that propiopromazine administration to the sheep not subjected to stress caused an increase in cortisol level by 125 per cent and that in glucose level by 35 per cent. These results suggest that propiopromazine administration protects the organism against the effects of emotional stress only partially. Moreover, the effect of its administration gradually weakens with repeating of the stress inducing experiment, and propiopromazine itself may act as a stress inducing factor. It seems therefore that the use of propiopromazine and similar compounds as anti-stress agents may be questionable.
本研究旨在评估吩噻嗪衍生物丙酰丙嗪（康必灵，拜耳公司生产）作为一种降低绵羊应激反应的药物的效果。通过将绵羊与羊群隔离1小时来诱导其产生情感性应激。在同一组绵羊身上重复进行6次隔离实验，前三次隔离（1 - 3次）每天进行一次，后三次（4 - 6次）每周进行一次。每次隔离实验前均给予丙酰丙嗪。给药后，绵羊对隔离应激的反应较弱。与未给药的隔离绵羊相比，血清皮质醇和葡萄糖水平的升高幅度较小，这表明了这一点。这种效果在第一次隔离实验过程中尤为明显；在接下来的实验中，给药组和未给药组绵羊在应激反应方面的差异逐渐减小。此外还发现，给未受应激的绵羊注射丙酰丙嗪会使皮质醇水平升高125%，葡萄糖水平升高35%。这些结果表明，丙酰丙嗪给药仅能部分保护机体免受情感应激的影响。此外，随着应激诱导实验的重复，其给药效果会逐渐减弱，而且丙酰丙嗪本身可能会作为一种应激诱导因素。因此，将丙酰丙嗪及类似化合物用作抗应激药物的做法可能存在疑问。
