Vodichenska Ts
Probl Khig. 1992;17:48-56.
A toxicological experiment on white male rats was carried out for one year. They received simultaneously per os nickel in doses 0.005 mg/kg and lead in doses 0.0025 mg/kg, equivalent respectively to the recommended by CMEA norms for nickel and hygienic norm for lead in drinking waters, as well as nickel and lead in doses 0.015 and 0.01 mg/kg, 0.015 and 0.1 mg/kg surpassing 3 and 4 times and 30 and 40 times the above mentioned norms or only nickel in doses 0.015 mg/kg, after which their effect on some enzyme indices was studied. Tests were made on: free sulfhydryl groups in blood serum, heart and liver; catalase activity of blood; cholinesterase activity and creatinphosphatase in blood serum; cytochromoxidase activity in liver and heart. It is established that in combined per os effect of nickel and lead in doses respectively 0.15 and 0.1 mg/kg and 0.015 and 0.01 mg/kg, as well as during independent effect of nickel with doses 0.015 mg/kg, occur disorders in the tissue breathing and oxyreduction processes. Nickel and lead in doses, equivalent to the hygienic norms, lead to no changes according to all studied indices.
对雄性白色大鼠进行了为期一年的毒理学实验。它们同时经口摄入剂量为0.005毫克/千克的镍和剂量为0.0025毫克/千克的铅，这分别相当于经互经会推荐的饮用水中镍的标准以及铅的卫生标准，还有剂量为0.015毫克/千克和0.01毫克/千克、0.015毫克/千克和0.1毫克/千克的镍和铅，分别超过上述标准3倍和4倍、30倍和40倍，或者只摄入剂量为0.015毫克/千克的镍，之后研究它们对某些酶指标的影响。进行了以下测试：血清、心脏和肝脏中的游离巯基；血液中的过氧化氢酶活性；血清中的胆碱酯酶活性和肌酸磷酸酶；肝脏和心脏中的细胞色素氧化酶活性。结果表明，镍和铅分别以0.15毫克/千克和0.1毫克/千克以及0.015毫克/千克和0.01毫克/千克的剂量经口联合作用时，以及镍以0.015毫克/千克的剂量单独作用时，组织呼吸和氧化还原过程会出现紊乱。与卫生标准相当剂量的镍和铅，根据所有研究指标均未导致变化。
