Vodichenska Ts, Bŭdeva B
Probl Khig. 1993;18:50-62.
During an annual toxicological experiment on white male rats, receiving orally vanadium (V) and nickel (Ni) in doses, equivalent to the accepted in Bulgaria, maximum allowable norms for ist category surface waters (respectively 0.005 mg/kg and 0.0025 mg/kg), 2 and 6 times and 20 and 60 times higher, is studied the atherogenic effect of the latter after the indices: total cholesterol, beta-lipoproteins, phospholipids, lecithin, total lipids, total protein and hexoses of glycoproteins in the serum; oxyproline, hexauranium acids and hexoses, hexosamines, connected with the proteins in the aorta. It is established that V and Ni in chronic combined effect in doses, equivalent to those accepted in Bulgaria, in maximum allowable concentrations for Ist category waters and surpassing them 2 and 6 time respectively, lead to no changes in the biochemical composition of the connective tissue of the aorta and to disorders in the lipidic and protein metabolism, while in higher doses is registered an increase of the glucoproteins and decrease in the glucosaminglycans in the aorta and decrease of the total lipids in the serum. The results point out, that V and Ni in the conditions of the experiment don't accelerate the processes of the natural ageing of the vessels and have no atherogenic effect. Juxtaposing the data for V and Ni concentrations in drinking waters in Bulgaria with our results give grounds to reckon, that their raised content in drinking waters in some regions do not represent a risk factor for the development of atherosclerosis.
在一项针对雄性白鼠的年度毒理学实验中，给白鼠口服钒（V）和镍（Ni），剂量分别相当于保加利亚规定的I类地表水最大允许含量的2倍、6倍、20倍和60倍（分别为0.005毫克/千克和0.0025毫克/千克），之后根据血清中总胆固醇、β-脂蛋白、磷脂、卵磷脂、总脂质、总蛋白和糖蛋白中的己糖；以及主动脉中与蛋白质相关的羟脯氨酸、己糖醛酸、己糖、己糖胺等指标，研究镍的致动脉粥样硬化作用。结果表明，钒和镍以慢性联合作用，在相当于保加利亚I类水最大允许浓度以及分别超过该浓度2倍和6倍的剂量下，不会导致主动脉结缔组织生化成分发生变化，也不会引起脂质和蛋白质代谢紊乱，但在更高剂量下，主动脉中的糖蛋白增加，氨基葡聚糖减少，血清中的总脂质减少。结果指出，在实验条件下，钒和镍不会加速血管自然老化过程，也没有致动脉粥样硬化作用。将保加利亚饮用水中钒和镍的浓度数据与我们的结果进行对比，有理由认为，某些地区饮用水中它们含量的升高并非动脉粥样硬化发展的风险因素。
