Shwe T, Hla K K
Clinical Research Unit, Department of Medical Research, Yangon, Myanmar.
Southeast Asian J Trop Med Public Health. 1992 Sep;23 Suppl 4:117-21.
The effect of artemether plus mefloquine versus quinine on 35 patients with complicated falciparum malaria including 5 patients with cerebral malaria were studied. All patients treated with the artemether-mefloquine combination survived and all were free from toxic effects of the drugs. Three patients on quinine therapy died. The mortality rate was 8.5%. The mean parasite clearance time of patients treated with artemether plus mefloquine was significantly shorter than those treated with quinine but there was no significant difference in the mean fever clearance of the two groups of patients. There was no recrudescence with artemether and mefloquine; the recrudescence rate was 5.5% with quinine. The study showed that the artemether-mefloquine combination is superior to quinine for the treatment of patients with complicated falciparum malaria, including cerebral malaria.
研究了蒿甲醚加甲氟喹与奎宁对35例复杂恶性疟患者（包括5例脑型疟患者）的疗效。所有接受蒿甲醚 - 甲氟喹联合治疗的患者均存活，且均未出现药物毒性反应。3例接受奎宁治疗的患者死亡。死亡率为8.5%。接受蒿甲醚加甲氟喹治疗的患者平均寄生虫清除时间明显短于接受奎宁治疗的患者，但两组患者的平均热退时间无显著差异。蒿甲醚和甲氟喹治疗无复发；奎宁的复发率为5.5%。该研究表明，蒿甲醚 - 甲氟喹联合用药在治疗包括脑型疟在内的复杂恶性疟患者方面优于奎宁。
