Bystron J, Petrek M, Hermanová Z, Ordeltová M
Department of Allergy and Clinical Immunology, University Hospital, Olomouc, Czechoslovakia.
Acta Univ Palacki Olomuc Fac Med. 1992;134:65-8.
The authors present an analysis of the results of laboratory immunological examination of 52 patients suffering from recurrent respiratory infections. Besides the typical laboratory correlates of chronic inflammation, several findings indicated the depressed function of cellular and partially humoral immunity. The immunological parameters, most frequently decreased in comparison with normal values, were as follows: the response to the recall antigens of Imunoskintest (lower in 54% of patients), the relative number of CD3+ lymphocytes (35%), the CD4/CD8 ratio (37%), phagocytic activity (37%) and also serum IgA (12%). This means that more than two thirds of patients displayed at the time of examination a substantial alteration of one or more immunological parameters, the depression of cellular immunity was much more pronounced. It is concluded that the laboratory immunological examination of patients with recurrent respiratory infections is very important for revealing of an underlying cause of the disease and for indicating the adequate immunomodulatory treatment.
作者对52例复发性呼吸道感染患者的实验室免疫检查结果进行了分析。除了慢性炎症的典型实验室相关指标外，一些发现表明细胞免疫功能和部分体液免疫功能受到抑制。与正常值相比，最常降低的免疫参数如下：免疫皮肤试验对回忆抗原的反应（54%的患者较低）、CD3 + 淋巴细胞的相对数量（35%）、CD4/CD8比值（37%）、吞噬活性（37%）以及血清IgA（12%）。这意味着超过三分之二的患者在检查时出现了一种或多种免疫参数的显著改变，细胞免疫抑制更为明显。得出的结论是，对复发性呼吸道感染患者进行实验室免疫检查对于揭示疾病的潜在原因和指明适当的免疫调节治疗非常重要。
