反复呼吸道感染学龄前儿童的免疫球蛋白水平及功能
Immunoglobulin levels and function in pre-school children with recurrent respiratory infections.
作者信息
Isaacs D, Webster A D, Valman H B
出版信息
Clin Exp Immunol. 1984 Nov;58(2):335-40.
Abstract
Thirty pre-school children with recurrent respiratory infections had a higher age adjusted mean serum IgG level than their siblings or a reference group. One index child had persistently low serum IgA, but mean serum IgA and IgM levels for the index children were normal. All of the 23 index children and 17 siblings studied had a four-fold or greater rise in virus neutralizing antibody titre. There was no correlation between serum immunoglobulin levels and frequency of infections. There was, however, a significant inverse correlation between salivary IgA levels when healthy and the number of infections experienced by each child in the study year. Salivary IgA levels rose considerably during acute infections.
摘要
30名反复发生呼吸道感染的学龄前儿童经年龄校正后的平均血清IgG水平高于其兄弟姐妹或参照组。一名指标儿童的血清IgA持续偏低，但指标儿童的血清IgA和IgM平均水平正常。所研究的23名指标儿童和17名兄弟姐妹的病毒中和抗体效价均有四倍或更高的升高。血清免疫球蛋白水平与感染频率之间无相关性。然而，健康时的唾液IgA水平与研究年度内每个儿童经历的感染次数之间存在显著的负相关。在急性感染期间，唾液IgA水平大幅上升。
相似文献
1
Immunoglobulin levels and function in pre-school children with recurrent respiratory infections.反复呼吸道感染学龄前儿童的免疫球蛋白水平及功能
Clin Exp Immunol. 1984 Nov;58(2):335-40.
2
[Immunoglobulin levels at different ages in the healthy child population].[健康儿童群体不同年龄段的免疫球蛋白水平]
Allergol Immunopathol (Madr). 1981 Jan-Feb;9(1):19-24.
3
Immunoglobulins and innate factors of immunity in saliva of children prone to respiratory infections.易患呼吸道感染儿童唾液中的免疫球蛋白及先天免疫因子
Acta Pathol Microbiol Immunol Scand C. 1987 Feb;95(1):35-40. doi: 10.1111/j.1699-0463.1987.tb00006.x.
4
An attempt to determine the relation between levels of IgG, IgA and IgM immunoglobulins and titers of antibodies against RS virus.一项旨在确定IgG、IgA和IgM免疫球蛋白水平与抗呼吸道合胞病毒抗体滴度之间关系的研究。
Arch Immunol Ther Exp (Warsz). 1977;25(4):477-82.
5
[Quantitative changes of serum immunglobulins during infectous diseases in childhood (author's transl)].儿童感染性疾病期间血清免疫球蛋白的定量变化（作者译）
Klin Padiatr. 1975 Jul;187(4):323-30.
6
[Salivary IgA in a group of children with recurrent respiratory infections].[一组反复呼吸道感染儿童的唾液免疫球蛋白A]
Minerva Pediatr. 1989 Apr;41(4):205-8.
7
Evaluation of secretory IgA childhood respiratory diseases.儿童呼吸道疾病中分泌型免疫球蛋白A的评估。
Allergol Immunopathol (Madr). 1988 May-Jun;16(3):157-61.
8
B- and T-cells and intracellular Ig-synthesis of peripheral lymphocytes in children with asthma and/or previous adeno-tonsillectomy.哮喘和/或既往接受过腺样体扁桃体切除术的儿童外周淋巴细胞中的B细胞、T细胞及细胞内免疫球蛋白合成
Acta Pathol Microbiol Scand C. 1977 Dec;85C(6):454-62.
9
10
IgM and IgD concentrations in the serum and secretions of children with selective IgA deficiency.选择性IgA缺乏症患儿血清和分泌物中的IgM和IgD浓度。
Clin Exp Immunol. 1983 Sep;53(3):689-96.
引用本文的文献
1
High Respiratory Tract Infection Rate in Patients With Familial Mediterranean Fever.家族性地中海热患者呼吸道感染率高。
Cureus. 2022 Sep 28;14(9):e29700. doi: 10.7759/cureus.29700. eCollection 2022 Sep.
2
Pidotimod: In-depth review of current evidence.匹多莫德：当前证据的深入综述
Lung India. 2019 Sep-Oct;36(5):422-433. doi: 10.4103/lungindia.lungindia_39_19.
3
The Salivary IgA Flow Rate Is Increased by High Concentrations of Short-Chain Fatty Acids in the Cecum of Rats Ingesting Fructooligosaccharides.摄入低聚果糖的大鼠盲肠中高浓度短链脂肪酸会增加唾液IgA流速。
Nutrients. 2016 Aug 17;8(8):500. doi: 10.3390/nu8080500.
4
Comparison of salivary IgA secretion rate collected by the aspiration method and swab method.比较抽吸法和拭子法收集的唾液 IgA 分泌率。
Biosci Microbiota Food Health. 2013;32(3):107-12. doi: 10.12938/bmfh.32.107. Epub 2013 Jul 25.
5
Effect of type of TAG fatty acids on lutein and zeaxanthin bioavailability.TAG 脂肪酸类型对叶黄素和玉米黄质生物利用度的影响。
Br J Nutr. 2013 Jul 14;110(1):1-10. doi: 10.1017/S0007114512004813. Epub 2012 Dec 11.
6
Developmental profiles of mucosal immunity in pre-school children.学龄前儿童黏膜免疫的发育概况
Clin Dev Immunol. 2010;2010:196785. doi: 10.1155/2010/196785. Epub 2010 Dec 27.
7
Exercising in environmental extremes : a greater threat to immune function?在极端环境中锻炼：对免疫功能构成更大威胁？
Sports Med. 2006;36(11):941-76. doi: 10.2165/00007256-200636110-00003.
8
Salivary IgA response to prolonged exercise in a hot environment in trained cyclists.训练有素的自行车运动员在炎热环境中长时间运动时唾液中免疫球蛋白A的反应。
Eur J Appl Physiol. 2005 Mar;93(5-6):665-71. doi: 10.1007/s00421-004-1270-7. Epub 2004 Nov 20.
9
Chronic cough in a hospital population; its relationship to atopy and defects in host defence.医院人群中的慢性咳嗽；其与特应性及宿主防御缺陷的关系。
Arch Dis Child. 1989 Nov;64(11):1593-8. doi: 10.1136/adc.64.11.1593.
本文引用的文献
1
VIRUSES IN ACUTE RESPIRATORY INFECTION IN A GENERAL COMMUNITY.普通社区急性呼吸道感染中的病毒
J Hyg (Lond). 1965 Mar;63(1):155-67. doi: 10.1017/s0022172400045046.
2
Serum immunoglobulin concentrations in preschool children measured by laser nephelometry: reference ranges for IgG, IgA, IgM.采用激光散射比浊法测定学龄前儿童血清免疫球蛋白浓度：IgG、IgA、IgM的参考范围
J Clin Pathol. 1983 Oct;36(10):1193-6. doi: 10.1136/jcp.36.10.1193.
3
Selective infection of lower respiratory tract by respiratory viruses in children with recurrent respiratory tract infections.反复呼吸道感染患儿呼吸道病毒对下呼吸道的选择性感染
Br Med J (Clin Res Ed). 1982 Jun 12;284(6331):1746-8. doi: 10.1136/bmj.284.6331.1746.
4
Deficiency of T helper cells in transient hypogammaglobulinemia of infancy.婴儿期暂时性低丙种球蛋白血症中辅助性T细胞缺乏。
N Engl J Med. 1981 Nov 26;305(22):1307-13. doi: 10.1056/NEJM198111263052202.
5
The proteins in nasal secretion. II. A longitudinal study of IgA and neutralizing antibody levels in nasal washings from men infected with influenza virus.鼻分泌物中的蛋白质。II. 对感染流感病毒的男性鼻腔灌洗液中IgA和中和抗体水平的纵向研究。
JAMA. 1970 Feb 16;211(7):1157-61. doi: 10.1001/jama.211.7.1157.
6
IgA deficiency in children. A clinical study with special reference to intestinal findings.儿童IgA缺乏症。一项特别关注肠道检查结果的临床研究。
Arch Dis Child. 1971 Oct;46(249):665-70. doi: 10.1136/adc.46.249.665.
7
Protein composition of nasal secretion during respiratory virus infection.呼吸道病毒感染期间鼻分泌物的蛋白质组成。
Proc Soc Exp Biol Med. 1965 Aug-Sep;119(4):1169-76. doi: 10.3181/00379727-119-30406.
8
Selective IgA deficiency: presentation of 30 cases and a review of the literature.选择性IgA缺乏症：30例病例报告及文献综述
Medicine (Baltimore). 1971 May;50(3):223-36.
9
10
The role of nasal secretion and serum antibody in the rhinovirus common cold.
Am J Epidemiol. 1966 Sep;84(2):352-63. doi: 10.1093/oxfordjournals.aje.a120648.
Zotero 插件