Kifer-Wysocka E, Romanowska-Sarlej J, Matysiak W, Czerny K
Katedra i Zakład Histologii i Embriologii, Akademia Medyczna w Lublinie.
Ann Univ Mariae Curie Sklodowska Med. 1991;46:143-8.
White male [correction of female] rats were given Dexamethasone in a single dose 0.35 mg/24 hrs. Group I was given the drug once, group II--received it for 2 days, and group III--for 7 days. 24 hrs after the medicine had been given the mucous membrane of the stomach corpus was collected for examinations. There were performed: H+E staining, PAS reaction and histochemical reaction to the activity of ATP-ase, acid phosphatase and alkaline phosphatase. The results obtained were compared with those obtained in a group of control animals which were given distilled water. The administration of Dexamethasone did not affect significantly the activity of the examined hydrolases, however, it damaged the mucous barrier of the stomach, specially in the animals after 7 days of application of the drug.
白色雄性[将“雌性”修正为“雄性”]大鼠接受了单次剂量为0.35毫克/24小时的地塞米松。第一组大鼠给药一次，第二组给药两天，第三组给药七天。给药24小时后，采集胃体黏膜进行检查。进行了苏木精-伊红染色、过碘酸雪夫反应以及对三磷酸腺苷酶、酸性磷酸酶和碱性磷酸酶活性的组织化学反应。将所得结果与给予蒸馏水的一组对照动物的结果进行比较。地塞米松的给药对所检测的水解酶活性没有显著影响，然而，它破坏了胃的黏液屏障，特别是在用药7天的动物中。
