Czerny K, Kifer-Wysocka E, Romanowska-Sarlej J, Kurnicka E
Katedra i Zakład Histologii i Embriologii z Pracownia Cytologii Doświadczalnej. Akademia Medyczna w Lublinie.
Ann Univ Mariae Curie Sklodowska Med. 1991;46:59-63.
Kidneys of the rats which had been intragastrically administered Dexamethasone (10 mg/kg), were examined. Observations were carried out after a single and twice repeated application of the preparation, as well as after 7 days of everyday administration. It was found, on the basis of histological and histochemical observations (reaction to alkaline phosphatase activity, reaction to acid phosphatase activity, PAS-method staining), that both single and twice administration of Dexamethasone do not cause the damage of the kidney parenchyma, whereas after 7 days of everyday application of the preparation irreversible changes can be observed.
对经胃内给予地塞米松（10毫克/千克）的大鼠肾脏进行了检查。在单次和两次重复给予该制剂后以及每天给药7天后进行了观察。基于组织学和组织化学观察（碱性磷酸酶活性反应、酸性磷酸酶活性反应、PAS法染色）发现，单次和两次给予地塞米松均不会导致肾实质损伤，而在每天应用该制剂7天后可观察到不可逆变化。
