Huskisson E C
Department of Rheumatology, St Bartholomew's Hospital, London, U.K.
Eur J Rheumatol Inflamm. 1991;11(2):8-12.
A four-way single-blind crossover study was used to compare the efficacy and tolerance of four non-steroidal anti-inflammatory drugs. In addition, pain intensity was compared during the day, at night, at rest, on walking, in the most painful joint, and with the patients most painful activity. Ninety-six patients with rheumatoid arthritis took single daily doses of controlled release naproxen (N), diclofenac S.R. (D), indomethacin S.R. (I) and standard piroxicam (P). The greatest changes from baseline after treatment were seen in those patients with the highest initial pain measurement scores. Assessments of pain in the morning, in the most painful joint and the most painful activity were more discriminating than those at noon or at rest. Of the treatments, 'N' and 'P' were the most effective in reducing pain, with statistically significant differences from baseline. 'I' was the most effective in reducing morning stiffness. Adverse experiences were generally mild, occurring more frequently on 'I' than on other treatments.
采用四向单盲交叉研究比较四种非甾体抗炎药的疗效和耐受性。此外，还比较了白天、夜间、休息时、行走时、最疼痛关节以及患者最疼痛活动时的疼痛强度。96例类风湿性关节炎患者每日单次服用控释萘普生（N）、双氯芬酸缓释片（D）、吲哚美辛缓释片（I）和标准吡罗昔康（P）。治疗后与基线相比变化最大的是那些初始疼痛测量分数最高的患者。早晨、最疼痛关节和最疼痛活动时的疼痛评估比中午或休息时更具区分性。在这些治疗中，“N”和“P”在减轻疼痛方面最有效，与基线相比有统计学显著差异。“I”在减轻晨僵方面最有效。不良反应一般较轻，在“I”治疗组比其他治疗组更频繁出现。
