Super M, Ezekowitz R A
Harvard Department of Pediatrics, Children's Hospital, Boston, MA 02115.
Infect Agents Dis. 1992 Aug;1(4):194-9.
The human mannose-binding protein (MBP) appears to function as an "ante-antibody" as its physiological role is in first line host defense. Low baseline serum levels are rapidly increased as part of the acute phase reactant and circulating MBP can act as a direct opsonin or activate the classical alternative complement pathway. MBP appears to selectively recognize an array of apparently disparate oligosaccharides that decorate gram-negative and gram-positive bacteria as well as certain parasites, yeasts, and fungi. MBP may be considered a "pattern" recognition molecule that has homologs in primitive life forms. Its ability to distinguish self from nonself indicates that it may play an important role in innate immunity.
人类甘露糖结合蛋白（MBP）似乎起着“前抗体”的作用，因为其生理作用是在宿主的第一道防线中发挥作用。作为急性期反应物的一部分，其低基线血清水平会迅速升高，循环中的MBP可作为直接调理素或激活经典替代补体途径。MBP似乎能选择性识别一系列明显不同的寡糖，这些寡糖存在于革兰氏阴性菌、革兰氏阳性菌以及某些寄生虫、酵母和真菌表面。MBP可被视为一种在原始生命形式中具有同源物的“模式”识别分子。它区分自身与非自身的能力表明，它可能在先天免疫中发挥重要作用。
